Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"Temozolomide"”.
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Mechanism of acquired temozolomide resistance in glioblastoma
… unclear. We isolated GBM cells resistant to temozolomide (TMZ), the frontline chemotherapy agent for GBM, and observed modest decreases in the mismatch repair (MMR) components MSH2 and MSH6. The modest decrease in MSH2, and relatively modest decrease in MSH6, did not seem sufficient to …
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Temozolomide and Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor
… 14 patients with advanced HPC/SFT who received temozolomide and bevacizumab systemic therapy, the overall RECIST response rate was 14%, with the overall Choi response rate of 79%. The median PFS for the cohort was 9.7 months with a median 6-month progression free rate of 78.6%. The most …
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DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy
… of surgery followed by radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. Prognosis is poor, with a median survival of 14.6 months following diagnosis. Treatment often fails due to intrinsic or acquired TMZ resistance of a small population of cells termed glioma cancer stem cells (GCSCs). …
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Overcoming toxicity and resistance limitations of the anticancer drug temozolomide
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Multifunctional Liposomal Carriers Encapsulating Temozolomide, RG7388 and Elacridar for Targeted Glioblastoma Multiforme Therapy
… and efflux through the simultaneous delivery of temozolomide, RG7388 and elacridar in a single nano-carrier system. Two liposomal systems were characterized including a multilamellar system and nanoparticles in liposome system (PLL) were designed for this purpose.|The liposomes were surface …
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… treatment with the chemotherapeutic agent temozolomide (TMZ) and radiotherapy. O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially oxidize glucose to lactate in glycolysis. This less …
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Studies on the mechanism of action on antitumour imidazotetrazinones
… are clinically active antitumour agents, temozolomide currently proving successful in the treatment of melanomas and gliomas. The exact nature of the biological processes underlying response are as yet unclear.This thesis attempts to identify the cellular targets important to the …
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A study of inter-individual differences in the DNA damage response
… focused our attention on the alkylating agents temozolomide and methylnitronitrosoguanidine (MNNG). While MNNG has been extensively studied as a model DNA damaging drug, temozolomide is used in the clinic today to treat astrocytoma and glioblastomas. The two drugs are often referred to as …
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Effect of combinations of drugs on glioma chemotherapy
… different concentrations of anticancer agents, Temozolomide, Cisplatin, and Paclitaxel alone and in combination for a period of 72 hours. Two combination studies involving the combination of Temozolomide and Cisplatin and the combination of Temozolomide and Paclitaxel revealed that Temozolomide …
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Investigation of Psychotropic Drugs for the Treatment of Glioblastoma
… followed by radiotherapy and chemotherapy with temozolomide, one of the few approved drugs for the treatment of glioblastoma. Unfortunately, most tumours develop resistance against temozolomide and therefore, new treatment modalities are urgently required. Meta-analysis of cancer in …
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Development of a novel combination radio- chemotherapy for glioblastoma multiforme
… beam radiotherapy and adjuvant and concomitant temozolomide chemotherapy. Treatment will fail due to an inherent treatment resistance, and as aresult, current treatment for glioblastoma has been designated as an unmet clinical need, meaning that new and more efficacious treatment options are …
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New applications of Imidazotetrazinone prodrugs. Synthesis and mechanistic investigation of novel imidazotetrazinones as prodrugs of aziridines and as traceless carriers for drug delivery to the central nervous system.
… of some these new tetrazines were similar to temozolomide, in addition to useful acid stability. Other imidazotetrazinones were synthesised for the purpose of releasing alcohols and phenols. Their synthesis was performed with a one-carbon linker between the imidazotetrazinone 3-position and …
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Local exposure and efficacy of a reservoir-based drug delivery device
… confirmed linear initial rates of release of temozolomide, an alkylating agent, and doxorubicin, a topoisomerase inhibitor, from the microcapsules. In vivo survival studies were conducted to compare the efficacies of these microcapsules against 9L rat gliosarcoma and CRL1666 rat mammary …
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Malignant Glioma: Chemosensitivity testing and Biomarkers
… cultures at passage 0. The drugs tested were Temozolomide, Cisplatin and Carmustine, which are commonly administered chemotherapeutic agents in clinical practice in our institution. The results revealed that cultures derived from females or from patients under 65 years of age were more …
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Microcapsule drug delivery device for treatment of glioblastoma multiforme
… devices for the localized delivery of temozolomide and for treatment of glioblastoma multiforme in this work. I have been able to modulate the drug release profiles from these microcapsules based on the physical chemistry of the drug and the dimensions of the release orifices in these …
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Effects of Concurrent Radiosensitization and Chemoradiotherapy for Brain Tumors
… includes surgical resection, chemotherapy and temozolomide (TMZ) as adjuvant therapy. The purpose of this work is to improve treatment outcomes for highly radioresistant and chemoresistant cancers employing nanoparticle mediated radiosensitization and chemoradiotherapy. Methods: We are using …
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