Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Telomere-independent senescence."”.
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Characterisation of the mechanisms of tumour-induced dysfunction of clonal T cell expansions in multiple myeloma
… of T cell clones into an anergic, exhausted or senescence phenotype was carried out to determine if dysfunction is reversible, since reversal of dysfunction is phenotype dependent. The cells exhibited a senescent secretory effector phenotype: KLRG-1+/CD57+/CD160+/CD28- with normal telomere …
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Investigation of a pancreatic derived progenitor cell population for use in regenerative medicine
… or as a direct in vivo cell therapy. Cellular senescence is a state of irreversible growth arrest that can be induced by multiple factors, including telomere dysfunction associated with replication and oxidant stress. Senescence of stem cell, or progenitor, populations has been proposed as a …