Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Telomerase regulation"”.
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Biochemical and structural studies of human telomerase regulation
Telomerase is a ribonucleoprotein (RNP) enzyme that extends telomeric repeats at eukaryotic chromosome ends (Blackburn and Collins, 2011; Blackburn et al., 2006; Greider et al., 1985; Morin, 1989; Nguyen, 2021). This counterbalances telomere loss caused by incomplete genome replication (Blackburn …
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Biochemical analysis of proteins in the telomere maintenance pathway
… of the specialized reverse transcriptase called telomerase. In addition to the function of telomerase, the telomere environment requires an efficient means to assemble and disassemble a multitude of structures to operate correctly and to help achieve cellular homeostasis. Distinct protein …
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A Critical Review of Telomerase Biology and Model Systems for the Study of Telomerase
The study of telomere and telomerase biology holds substantial promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… compound–perillyl alcohol regulates telomerase activity via the mammalian target of rapamycin (mTOR) pathway in prostate cancer cells. Telomerase–the enzyme responsible for immortalizing cells through telomeric repeats addition–is de-repressed early in an aspiring cancer cell. We …
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REGULATION OF TELOMERASE EXPRESSION IN STEM CELL REPROGRAMMING
… them from normal fibroblasts and their lack of telomerase shows their limited proliferation capacity, the expression of genes closely linked to pluripotency and their differentiation capacity clearly define ASCs as multipotent stem cells. iPS cells are another promising cell type for tissue …