Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Telomerase inhibition"”.
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer …
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Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
… this study was to determine whether GRN163L, a telomerase inhibitor, currently in clinical trials for the treatment of cancer, has enhanced anti-cancer activity in BRCA1 mutant breast/ovarian cancer cell lines compared to wild-type cancer cells. BRCA1 mutant cancer cells were observed to have …
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Telomere Length Studies in Human Cancer Cells
… of cancer cells achieve this by upregulating telomerase. Maintaining telomere length involves regulating the dynamic between telomere shortening and telomere elongation. However, there are still many aspects of this dynamic regulatory process that are unknown. Many methods of telomere length …
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
Telomerase is expressed in ~90% of all cancers but is not expressed in most somatic cells making it an attractive target for cancer therapy. Telomerase has two essential components, a reverse transcriptase (hTERT) and an RNA template (hTR or hTERC). The RNA template is used by the reverse …
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Structural and chemical studies of RNA as anti-cancer target and signaling molecule
… important RNA discussed in this dissertation are telomerase and extracellular microRNA. Telomerase is a ribonucleoprotein whose role has been implicated in cancer. Telomerase catalyses telomere extension by using a portion of its RNA as a template. During this process a RNA/DNA heteroduplex is …
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
… cancer cells through p53 stabilization and telomerase inhibition leading to cellular senescence. This growth-suppressive phenotype is the functional consequence of TTP's ability to promote rapid ARE-mRNA decay of the cellular ubiquitin ligase E6-AP, which is a key player in human …
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Auswirkungen der spezifischen Telomeraseinhibition mit BIBR 1532 auf CD 8+ T-Lymphozyten in vitro
… der Zahl der Zellteilungen verkürzen. Das Enzym Telomerase ermöglicht Tumorzellen durch Stabilisierung ihrer telomerischen Enden eine Überwindung des replikationsbedingten Telomerverlusts und damit der Erlangung einer unbegrenzten Wachstumskapazität. Daher ist die Telomeraseinhibition ein …