Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Telethonin"”.
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Computational Studies on the Mechanical Properties of Muscle and Blood Clot Elasticity
… in detail: the Z1Z2 domains bound to the protein telethonin at one end of the long protein chain in a relatively immobile region of the muscle fiber, and the I91 domain and 6-Ig tandem 165-70 located at titin's flexible I-band. SMD simulations of the Z1Z2-telethonin complex reveal that telethonin …
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… we identified a new sarcomeric target substrate, Telethonin(TCAP), which also shows circadian oscillation in its mRNA transcript and protein expression and, importantly, interaction with FBXL21 in an anti-phasic manner. Via computational and pharmacological tests, we identified Glycogen Synthase …
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The Role of Two Homologous E3 Ligases In Muscle Physiology
… a new shared target of FBXL3 and FBXL21: Telethonin (also known as TCAP). TCAP is a sarcomeric z-disc protein expressed in cardiac and skeletal muscle that is critical to proper structure and function of muscles. Through preliminary experiments, we identified TCAP as a novel shared target …