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Showing 1 to 20 of 20 for “"Technetium-99m"”.
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Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of octreotide analogues that differ in their sequences, and/or coordination systems …
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A Pretargeted Spect Imaging Strategy Employing Technetium-99M Based on Bioorthogonal Diels-Alder Click Chemistry
<p>A series of related N<sub>3</sub>S <sup>99m</sup>Tc-peptide complexes were synthesized and tested for use in pretargeting SPECT imaging that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory …
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Alternative design concepts for the electron to photon converter in the accelerator based production of technetium-99m
… is being studied for use in the production of 99mTc from enriched 100Mo by electron beam induced bremsstrahlung photons. Of primary concern to any radioisotope production system is the specific activity it is able to create of the radioisotope. In a photoneutronic production system maximizing …
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The role of Technetium-99m Sestamibi scintimammography to evaluate palpable breast lesions : a comparison with mammography and histological results
This study was conducted with the support of the Combined Breast Clinic at our institution which consists of the Departments of Surgery, Radiology and Radiation Oncology. The work was done in three parts. The literature showed somewhat lengthy imaging procedure for scintimammography which were not …
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The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma
The distinction between cavernous haemangiomas of the liver (which are the second most common hepatic mass lesions) from malignant lesions, is often difficult. An incorrect diagnosis of cavernous haemangioma, in a patient with malignancy, may adversely influence the outcome of subsequent treatment …
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I. Synthetic Approaches Towards 2-Fluoroestradiol. II. Synthesis and Evaluation of Tacn-Rhenium Complexes as Estrogen Receptor Imaging Agents
… with the widely available and less expensive technetium-99m radionuclide. We have explored the synthesis and evaluation of metal carbonyl complexes with 1,4,7-triazacyclononane. The results have suggested that these complexes are not suitable for ER imaging.
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Efeitos biológicos in vitro de agentes físicos utilizados em fisioterapia
The uses of radiobiocomplexes labeled with technetium-99m contributed to health science advances. Stannous chloride (SnCl2) has been used as a reducing agent for the labeling process. Cytotoxic and genotoxic effect of the SnCl2 have been described in several studies and with this experimental …
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Evaluating the role of a 99mTc-HYNIC-PSMA SPECT scan following a negative bone scan in men with prostate cancer: a single-centre, retrospective cohort study
… intermediate-risk prostate cancer, who had a 99mTc-HYNIC-PSMA SPECT (technetium-99m hydrazine nicotinamide prostate-specific membrane antigen singlephoton emission computerised tomography) scan following a negative 99mTc-MDP (technetium-99m methylene diphosphonate) bone scan. Materials and …
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Competition in the radioisotopes market: evaluation and analysis of drivers which affect mo-99 market share
… fission isotopes, Mo-99, which is used to create Technetium-99m(Tc-99m), is estimated to be utilized in roughly 85% of nuclear medicine diagnostic scans carried out globally (National Academies Press, 2009).
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In vitro comparison of methylene diphosphonate radiopharmaceuticals
… osteogenesis. MDP is chelated with radioactive technetium-99m (Tc99m) and injected into the venous system of the body. It quickly clears from the bloodstream and is deposited into areas of bone transformation. Osteoporosis, primary carcinoma, bony metastases, osteomyelitis, and stress fractures …
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Development of Receptor-Targeted Imaging Agents: Integrated Gallium Complexes and Conjugated Cyclopentadienyl Tricarbonyl Rhenium and Technetium Complexes
… Emission Computed Tomography (SPECT) imaging is 99mTc, the development of 99mTc-labeled phenyl-tropane analogs with high affinity for the dopamine transporter (DAT) would provide a useful tool for imaging disorders in this transporter system, such as clinical diagnosis of Parkinson's disease. The …
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The Synthesis and Characterization Of A Functionalized Diethylenetriamine Rhenium Complex Followed By Analytical Analysis of Novel Rhenium-Luteinizing Hormone-Releasing Hormone Conjugates
… of diseased states. Given the widespread use of technetium-99m (99mTc) in over 85% of radiopharmaceutical compounds, it is an ideal candidate for generating medically relevant organometallic complexes. The [99mTc(CO)3L]+ core, when facially chelated by tridentate ligands, shows superior …
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Efeito de preparações de produtos naturais (cravo da índia e tomate) e de um produto sintético na marcação de constituintes sangüineos com tecnécio-99m e na morfologia de hemácias isoladas de sangue de ratos wistar
… products. Blood constituents labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to study the effects of Clove (Caryophyllus aromaticas L.) and OZE (preparation used in the Health Sciences) on the labeling blood constituents with 99mTc and on the …
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Absolute Quantification of Tc-99M Activity Distributions Using A Planar Molecular Breast Imaging Commercial System
… to visualize the preferential uptake of technetium-99m-sestamibi (<sup>99m</sup>Tc-sestamibi) by breast cancer cells relative to surrounding benign breast tissues. Clinically, MBI is used primarily as a supplementary tool to standard-of-care mammography because of its improved detection …
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Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals
… that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom functionalities, at the periphery of DAB-PPI dendrimers, as potential 99mTc chelates. Monomeric ligands were also synthesized as model …
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Thermal-hydraulic optimization for high production of low-enriched uranium based molybdenum-99
Globally, more than 20 million samples of technetium-99 are used annually to diagnose many different forms of cancer. Despite this, there are only four main nuclear reactors worldwide that produce molybdenum-99, the parent isotope of technetium-99m. In an attempt to address the growing demand, as …
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Studies of gastric emptying in man
… (anterior) detection of indium-113m and technetium-99m were determined in studies with a rectilinear scanner and with a gamma camera.
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Novel Amino Acid Transporter-Targeted Radiotracers For Breast Cancer Imaging
… tyrosine analogues.</p> <p>In this study, four Technetium-99m (<sup>99m</sup>Tc) labeled tyrosine/ AMT (α-methyl tyrosine)-based radiotracers were successfully synthesized and evaluated for their potentials in breast cancer imaging. In order to radiolabel tyrosine and AMT, the chelators …
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Investigation of the synovial tissue-homing mechanisms of circulating mononuclear phagocytes in treatment-naïve psoriatic arthritis.
… of the cognate ligands on PsA endothelium. Using technetium-99m (Tc99m) monocyte radiolabelling studies, I show recruitment of monocytes to inflamed PsA joints. Spatial sequencing and imaging mass cytometry of biopsies from these patients show several foci of Tc99 positive cells in PsA synovium, …
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Rhenium and technetium-labeled progestins, the development of receptor-directed agents for diagnostic imaging or therapy
… labeled with the readily available radionuclide technetium-99m, three conjugate systems have been prepared in which a progestin is linked to a metal chelate system. These are bis-amino bis-thiol (BAT or N$\sb2$S$\sb2$) systems and are linked through carbon-21 of progesterone or the 17$\alpha$- or …