Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Tear fluid"”.
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Towards an improved ocular drug delivery system
… the information available on the nature of the tear fluid and its relationship with the eye. An extensive survey of the relevant literature was made. There is a common belief in the literature that the ocular glycoprotein, mucin, plays an important role in tear film stability, and furthermore, …
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Analytical techniques for the study of soft contact lens spoilation
… lenses that are better tolerated by the eye. The tear film is a complex biological fluid, it is this fluid that bathes the lens during wear. It is reasonable to suppose that it is material derived from this source that accumulates on the lens. To understand this phenomenon it was decided to …
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Drug delivery strategies to overcome ocular hypertension
… require frequent administration due to natural tear fluid turnover and blinking, which reduces patient compliance and can lead to complications, such as blurred vision and systemic toxicity. To address these limitations, this thesis explores two innovative drug delivery strategies using …
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Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
… a sol-gel transition in the presence of tear fluid in the eye to prolong drug contact time and enhance ocular bioavailability. Pre-formulation studies identified excipients that provided acceptable characteristics of clarity, isotonicity, and sterility to the ocular formulation. Using …
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Preparation, Characterization and Toxicity Evaluation of a Novel Sustained Release Delivery System for a Hydrogen Sulfide Donor - GYY 4137
… an in situ gel upon injecting in simulated tear fluid. Compared to aqueous GYY 4137 solution, the formulation sustained and extended the H2S release significantly (p < 0.05). Rheological study of the delivery system indicated a shear-thinning plastic flow with 43.89 ± 3.21 cP viscosity and …
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The tear film and contact lens wear
… material and the surrounding biological fluid. A common complaint of lens wearers is that they often experience symptoms of dry eye whilst wearing lenses. This sensation is often heightened towards the end of the day. Through the course of this study, various analytical techniques have …
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Analysis of the Role of Bacillus oleronius Proteins in the Induction of Rosacea and Evaluation of Novel Therapeutics for the Treatment of Dermal and Ocular Rosacea
… antigens. Mucin is naturally present in tear fluid and protects the epithelial barrier. This antimicrobial displayed potential as an adhesive decoy against antigen. A novel saline therapeutic was also investigated to treat rosacea patients and alleviate symptoms. The novel salt based …
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Tear protein interaction with hydrogel contact lenses
… comes into contact with most biological fluids. The eye is a unique body site for the study of protein interactions with biomaterials, because of its ease of access and deceptive complexity of the tears. The use of contact lenses for either vision correction and cosmetic reasons or as a …
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Untersuchungen zur Verbesserung der Kompatibilität und der Adhäsion zwischen dem künstlichen Epithel und der Hornhaut mittels eines Dentinhaftvermittlers
… clinical studies. The mechanic of eye-lids and tear fluid should be considered in particular. Proteolytic enzymes might interfere with the system as well. Clinical experiences will have to show if the complications occurring during the adhesion with the tissue glue Histoacryl can be prevented …
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In vitro Sustained Release Delivery System for Hydrogen Sulfide Analogs
… was injected in releasing media, simulated tear fluid (STF), it instantaneously formed a gel depot. NaHS when released from the depot, instantaneously releases hydrogen sulfide (H2S) due to hydrolysis. H2S would be entrapped into the releasing media by being soluble in water up to 176 mM at …