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Showing 1 to 12 of 12 for “"Tcdb"”.
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Toxina b y binaria como valor pronóstico en la infección por clostridioides difficile
… (cdtA) y la detección directa de toxina B (TcdB) en heces, con la aparición de enfermedad grave, complicada o recurrencias en una serie prospectiva de casos. 3. Método Se incluyen un total de 220 casos confirmados mediante un algoritmo en dos pasos: estudio inicial de detección de la enzima …
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Computational Approaches To Anti-Toxin Therapies And Biomarker Identification
… glucosylating toxins. These toxins, TcdA and TcdB cause severe intestinal damage. As Clostridium difficile harbors considerable antibiotic resistance, one treatment strategy is to prevent the tissue damage that the toxins cause. The catalytic glucosyltransferase domain of TcdA and TcdB was …
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Hypervirulent Clostridium Difficile Strains: Adherence, Toxin Production and Sporulation
… </italic>strains produce two toxins (TcdA and TcdB) during the stationary phase of growth. It has been suggested that hypervirulent <italic> C. difficile </italic>strains produce higher amounts of toxin, and that a mutation in a negative regulator (TcdC) allows for toxin production at all …
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Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/b And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression
… with broad-spectrum antibiotic usage. TcdA and TcdB</p> <p>are the key virulence factors involved in major patho-physiology. While standard</p> <p>antibiotics provide some respite, due to the high relapse rates and the emergence of more</p> <p>severe disease presentations, antibiotics alone have …
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Impacto de la neumonía asociada a ventilación mecánica en el traumatismo cráneo encefálico grave
… (4 puntos); la lesión craneal valorada por la TCDB y los días de VM previos al diagnóstico de neumonía. Resultados. Comparando los pacientes con y sin NAV, no hubo diferencias significativas en la mortalidad hospitalaria (20,8% vs 15,3%, p = 0,54), aunque sí en los días de estancia en UCI [21 …
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Assays for lycosyltransferases
… other GTs: bovine β1,4-galactosyltransferase, TcdB from Clostridium difficile and NGT from Actinobacillus <br/>pleuropneumoniae. The validated LDA was used for screening two compound libraries (c. 400 compounds in total) against LgtC for the first time. Positive hits were identified from both …
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Holin-dependent secretion of a large clostridial cytotoxin by C. perfringens
… toxins (LCTs). These LCTs include TcdA and TcdB in C. difficile, TcsL and TcsH in P. sordellii, and TpeL in C. perfringens. LCTs bind and inactivate small GTPases in host mammalian cells, shutting down cell-signaling and eventually leading to cell death. Intriguingly, LCTs all lack any …
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Estudio descriptivo de la microbiota intestinal en pacientes con infección por Clostridium difficile y en individuos colonizados por Clostridium difficile.
… es debida a la producción de las toxinas TcdA y TcdB de acción citotóxica. No obstante, la colonización intestinal de C. difficile puede dar lugar a un abanico de situaciones como la ausencia de síntomas (individuos colonizados) hasta diarrea grave o colitis pseudomembranosa fulminante …
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Strukturelle und mechanistische Arbeiten an Triterpen-Cyclasen aus Alicyclobacillus acidocaldarius und Arabidopsis thaliana sowie Kristallstrukturen der katalytischen Fragmente von AB-Toxinen aus Clostridium difficile und Bacillus sphaericus
… bei einer Auflösung von 2.2 Å bestimmt werden. TcdB gehört der Familie der großen clostridialen Toxine an und modifiziert kleine GTP-bindende Proteine des Wirts durch Transfer einer als UDP-Zucker aktivierten Glucose. Die Strukturlösung gelang durch die Kombination von Phasensätzen zweier …
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Régulation du c-di-GMP et rôle de ce messager secondaire dans la formation de pili de type IV chez Clostridium difficile.
… indirectement la production des toxines TcdA et TcdB. La démonstration de l’effet positif du c-di-GMP sur l’agrégation des cellules via les T4P, dans la deuxième partie de mon doctorat, contribue à notre compréhension de la signalisation à c-di-GMP chez C. difficile. Il apparait que le c-di-GMP …
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The structure, biophysics and bioengineering of secretory immunoglobin A
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01