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Showing 1 to 13 of 13 for “"Tcda"”.

  1. Charakterisierung der inhibitorischen Wirkung von Ambroxol auf die Toxine TcdA, TcdB und CDT von C. difficile

    Baier, Jan EricUniversität Ulm

    ulm-diss Repository record

  2. Over-expression in Escherichia coli of the ToxA51 llama single domain antibody targeting Clostridium difficile enterotoxin A

    Parisien, AlbertUniversity of Ottawa (Canada)2013

    … neutralizing, Clostridium difficile toxin A (TcdA) has been developed. The antibiotic resistant version of C. difficile bacterium is of major health concern worldwide, particularly in hospital settings, causing severe gastrointestinal disorders. In this study, we investigated various …

    ottawa-retro Repository record

  3. Computational Approaches To Anti-Toxin Therapies And Biomarker Identification

    Swett, Rebecca Jane2013

    … two large glucosylating toxins. These toxins, TcdA and TcdB cause severe intestinal damage. As Clostridium difficile harbors considerable antibiotic resistance, one treatment strategy is to prevent the tissue damage that the toxins cause. The catalytic glucosyltransferase domain of TcdA and …

    wayne-thes Repository record

  4. Hypervirulent Clostridium Difficile Strains: Adherence, Toxin Production and Sporulation

    Merrigan, Michelle Marie2016

    … difficile </italic>strains produce two toxins (TcdA and TcdB) during the stationary phase of growth. It has been suggested that hypervirulent <italic> C. difficile </italic>strains produce higher amounts of toxin, and that a mutation in a negative regulator (TcdC) allows for toxin production at …

    loyola-thes Repository record

  5. Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/b And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression

    Abdeen, Sanofar Jainul2012

    … associated with broad-spectrum antibiotic usage. TcdA and TcdB</p> <p>are the key virulence factors involved in major patho-physiology. While standard</p> <p>antibiotics provide some respite, due to the high relapse rates and the emergence of more</p> <p>severe disease presentations, antibiotics …

    wayne-thes Repository record

  6. Wideband Low-Profile Antenna Arrays: Fundamental Limits and Practical Implementations

    Doane, Jonathan P.The Ohio State University2013

    … Coupled Dipole Array with Integrated Balun (TCDA-IB), and it achieves 7.35:1 bandwidth while maintaining a low VSWR of ≤ 2.65:1 while scanning to ± 45° in all planes. A prototype 8×8 array was constructed and demonstrated excellent performance relative to simulation. We also demonstrate that …

    ohiolink Repository record

  7. Development of a cargo delivery system and inhibition studies focused on clostridium difficile toxin a

    Kern, Stephanie Marie2012

    … difficile toxin A fusion protein, luciferase-TcdA, and evidence of the successful transport of an active enzyme, luciferase, into the cytosol of vero cells. A feature that makes our system so attractive, is the auto-proteolytic event that releases the cargo protein after internalization. In …

    wayne-thes Repository record

  8. Holin-dependent secretion of a large clostridial cytotoxin by C. perfringens

    Flynn, Nathaniel HintonVirginia Tech2025

    … clostridial toxins (LCTs). These LCTs include TcdA and TcdB in C. difficile, TcsL and TcsH in P. sordellii, and TpeL in C. perfringens. LCTs bind and inactivate small GTPases in host mammalian cells, shutting down cell-signaling and eventually leading to cell death. Intriguingly, LCTs all lack …

    vt Repository record

  9. Estudio descriptivo de la microbiota intestinal en pacientes con infección por Clostridium difficile y en individuos colonizados por Clostridium difficile.

    Sánchez Pellicer, Pedro2020

    … clínica es debida a la producción de las toxinas TcdA y TcdB de acción citotóxica. No obstante, la colonización intestinal de C. difficile puede dar lugar a un abanico de situaciones como la ausencia de síntomas (individuos colonizados) hasta diarrea grave o colitis pseudomembranosa fulminante …

    murcia-diss Repository record

  10. Die Beteiligung von Chaperonen an der Aufnahme von clostridialen Proteintoxinen in das Zytosol von Säugetierzellen

    Kroll, ClaudiaUniversität Ulm

    ulm-diss Repository record

  11. Clostridium difficile: expression of virulence factors, resistance to disinfectants and interactions with human cells

    Vohra, PrernaThe University of Edinburgh2012

    … The transcription of the pathogenicity locus (tcdA-E) that regulates toxin production in C. difficile, and of spo0A, the initiator of sporulation, was studied. There were three key observations: firstly, the transcription of tcdC, the negative regulator of toxin production, did not decrease …

    edinburgh Repository record

  12. Régulation du c-di-GMP et rôle de ce messager secondaire dans la formation de pili de type IV chez Clostridium difficile.

    Bordeleau, ÉricUniversité de Sherbrooke2014

    … inhibe indirectement la production des toxines TcdA et TcdB. La démonstration de l’effet positif du c-di-GMP sur l’agrégation des cellules via les T4P, dans la deuxième partie de mon doctorat, contribue à notre compréhension de la signalisation à c-di-GMP chez C. difficile. Il apparait que le …

    sherbrooke Repository record

  13. The structure, biophysics and bioengineering of secretory immunoglobin A

    Kumar Bharathkar, SonyaUniversity of Illinois at Urbana-Champaign2023

    Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01

    uiuc Repository record