Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tbx20"”.
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Functional analysis of tcf21 and tbx20 in zebrafish
… Transcription factors, such as tcf21 and tbx20, bind to regulatory elements of DNA and can either upregulate or downregulate nearby genes. To build this gene regulatory network, scientists use a technique called ChIP-seq that can determine where in the genome these transcription factors …
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Tbx20 - Ein essentieller Regulator der Entwicklung des atrioventrikulären Kanals im Zebrafisch
… dass der whz-Phänotyp durch einen Gendefekt in tbx20, einem Tbox-Transkriptionsfaktor, hervorgerufen wird, der zum partiellen Verlust der transkriptorischen Aktivatorfunktion führt. Die loss of function- Mutation in tbx20 wurde durch einen genetischen rescue von whz durch WT-tbx20 bestätigt. Die …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… [7], and eye of <em>Drosophila</em> [8]. The <em>Tbx20</em> gene represents the conserved vertebrate ortholog of <em>mid</em>. Experimental evidence suggests that Tbx20 regulates cell proliferation within the embryonic chamber of the mouse myocardium; <em>Tbx20</em><sup>-/-</sup> null mice exhibit …
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The genetics of atrial septal defect and patent foramen ovale
… the GATA4 gene. The cardiac transcription factor TBX20 interacts with other ASD genes but had not previously been associated with human disease. Of 352 individuals with CHD, including 175 with ASD, 2 individuals, each with a family history of CHD, had pathogenic mutations in TBX20. Phenotypes …
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An investigation into a role for follistatin in early cardiogenesis in Xenopus Laevis
… we first showed that excess RA inhibits Tbx20 gene expression in the heart-forming region. This provides another mechanism by which excess RA inhibits cardiogenesis in addition to the known inhibition of Nkx2.5 expression and BMP signaling.
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… (mid)</em>, a homolog to the human <em>TBX20 </em>gene, interacts with <em>dFOXO </em>within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle (IOB) formation. Previous studies have identified <em>mid</em>’s role in …
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Detection of Genes Influencing Chronic and Mendelian Disease Via Loss-of-Function Variation
… <em>NF1</em>, <em>NR2F2</em>, <em>PLRG1, SMURF1, TBX20</em>,<em> </em>and<em> ZEB2</em>).</p> <p>The analytical strategy presented here highlights the role of biologically-informed annotation on large-scale human genetic studies. The genes identified by these methods may have applications in …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… for c-kit, Foxh1, Hand1, Hand2, Pitx2, Tbx5, Tbx20, Hrt1, Hrt2, Fgf8, Fgf10, and Isl1 were found at differential levels in c-kitpos CSCs isolated from the four cardiac chambers. Conclusion: This study is the first to show that c-kitpos eCSCs derived from human adult cardiac samples, do not …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… which can be repressed by a transcription factor Tbx20. Meis1 appears to play a complicated role in the blood vessels. Although the major blood vessels are still normal when global deletion of Meis1, the intersegmental vessel cannot be formed in Meis1 morphants in the zebrafish, and the small …