Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Tbx1"”.
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
<p><strong>Enforced expression of <em>Tbx1</em> in fetal thymic epithelial cells antagonizes</strong></p> <p><strong>thymus organogenesis</strong></p> <p>Kim T. Cardenas</p> <p>The thymus and parathyroid glands originate from organ-specific domains of 3rd pharyngeal pouch (PP) endoderm. At …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… or parathyroid lineage are not well defined. <em>Tbx1</em> is initially expressed throughout the 3<sup>rd</sup> pp endoderm, as it is required for segmentation of the pharyngeal apparatus, but is downregulated in the thymus-fated domain by E10.5. Despite the widely held notion that <em>Tbx1 …
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Zebrafish Cardiac Development Requires a Conserved Secondary Heart Field
… fields. Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.</p>
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Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection
… Lastly, copy number detection of the TBX1 was performed when multiplexed with the TREC assay, without a decrease in detection limit of either assay. Here, we provide proof of principal that qPCR multiplexing technologies are amenable to implementation with a newborn screening …
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Funktionelle Analyse des murinen Sall4-Gens
… eine starke Abnahme im Expressionlevel von Tbx1 and Tbx5, dagegen ist die Expression dieser Gene in Sall4 heterozygoten Embryos kaum beeinträchtigt. Dies weist daraufhin, dass die Expression von T-box Genen, die an der frühen Kardiogenese beteiligt sind, möglicherweise durch Sall4 reguliert …
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Investigation of Copy Number Variation in South African Patients with Congenital Heart Defects
… genes known to be causal for CHD (GATA4, TBX1, FLT4, CRKL, NSD1, and B3GAT3), and four CNVs encompassing candidate genes likely to play a role in the development of CHD (DGCR8, JARID2, KDM2A, and FSTL1). The CNVs were identified in nine unrelated individuals: five of the CNVs were …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… expression changes for 3 selected genes, Tbx1, Bmp7, and Jag1, both in primary keratinocytes and in Wild-type and Tabby whole skin, by Q-PCR and Western blotting analyses. Thus, this study detected novel candidate pathways downstream of EDA. In the second part of the research project, …