Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Tbx1"”.
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
<p><strong>Enforced expression of <em>Tbx1</em> in fetal thymic epithelial cells antagonizes</strong></p> <p><strong>thymus organogenesis</strong></p> <p>Kim T. Cardenas</p> <p>The thymus and parathyroid glands originate from organ-specific domains of 3rd pharyngeal pouch (PP) endoderm. At …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… or parathyroid lineage are not well defined. <em>Tbx1</em> is initially expressed throughout the 3<sup>rd</sup> pp endoderm, as it is required for segmentation of the pharyngeal apparatus, but is downregulated in the thymus-fated domain by E10.5. Despite the widely held notion that <em>Tbx1 …
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Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
… and function of the T-box transcription factor Tbx1 were examined in wild-type and Tbx1 null mutant mouse embryos. Tbx1 immunoreactivty was present in the splanchic mesoderm adjacent to the thyroid but not in the thyroid progenitors. The thyroid of Tbx1 deficient embryos was severely dysplastic …
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Zebrafish Cardiac Development Requires a Conserved Secondary Heart Field
… fields. Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.</p>
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Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection
… Lastly, copy number detection of the TBX1 was performed when multiplexed with the TREC assay, without a decrease in detection limit of either assay. Here, we provide proof of principal that qPCR multiplexing technologies are amenable to implementation with a newborn screening …
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Funktionelle Analyse des murinen Sall4-Gens
… eine starke Abnahme im Expressionlevel von Tbx1 and Tbx5, dagegen ist die Expression dieser Gene in Sall4 heterozygoten Embryos kaum beeinträchtigt. Dies weist daraufhin, dass die Expression von T-box Genen, die an der frühen Kardiogenese beteiligt sind, möglicherweise durch Sall4 reguliert …
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Investigation of Copy Number Variation in South African Patients with Congenital Heart Defects
… genes known to be causal for CHD (GATA4, TBX1, FLT4, CRKL, NSD1, and B3GAT3), and four CNVs encompassing candidate genes likely to play a role in the development of CHD (DGCR8, JARID2, KDM2A, and FSTL1). The CNVs were identified in nine unrelated individuals: five of the CNVs were …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… expression changes for 3 selected genes, Tbx1, Bmp7, and Jag1, both in primary keratinocytes and in Wild-type and Tabby whole skin, by Q-PCR and Western blotting analyses. Thus, this study detected novel candidate pathways downstream of EDA. In the second part of the research project, …