Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Tauopathies"”.
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Connectivity biomarkers in neurodegenerative tauopathies
The primary tauopathies are a group of neurodegenerative diseases affecting movement and cognition. In this thesis I study Progressive Supranuclear Palsy (PSP) and the Corticobasal Syndrome (CBS), two parkinsonian disorders associated with accumulation of hyperphos- phorylated and abnormally folded …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
The neurodegenerative tauopathies include Alzheimer’s disease, frontotemporal dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each characterised by neuroinflammation, with increasing evidence that the …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… and what role if any this may be playing in tauopathies. We show that EP3Re is expressed throughout the brain, with strong expression in brain stem nuclei, and signals predominantly through a Gi coupling pathway. Moreover, using a combination of human tissue, primary cell lines and neurons …
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Synaptic loss in the primary tauopathies of Progressive Supranuclear Palsy and Corticobasal Degeneration
… symptom of cognitive dysfunction in the primary tauopathies of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD). Both PSP and CBD are associated with an accumulation of 4-repeat tau in cortical and subcortical areas. As well as movement disorders, they impair cognitive …
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Single-molecule profiling of tau aggregates in tauopathies: From test tube to patient
… very low concentrations. A notable example are tauopathies, a group of neurodegenerative diseases in which pathological aggregation of the tau protein plays a central role. Current approaches often fail to resolve the small, early-stage tau aggregates that are believed to be a major neurotoxic …
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Identify Signature Genes/Pathways to Characterize Alzheimer's Disease Subtypes Based on Uncoupled Tauopathies and Cognitive Decline
Alzheimer's disease (AD) is a slow-progressing dementia usually found in elderlies, with heterogeneous clinical phenotypes and possible underlying mechanisms. Widely spread tauopathy is one of the pathological change hallmarks in AD brains, in which microtube protein tau forms scar-like …
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Digitally quantified neuropathological correlates of structural and functional imaging biomarkers in progressive supranuclear palsy
… for differential diagnosis in neurodegenerative tauopathies. However, the relationship between imaging changes and neuropathology requires more thorough validation and beyond Alzheimer’s disease. In tauopathies, tau is the key protein where specific pattern of tau aggregation and distribution can …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
… their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3b or stress-activated protein kinase 4 enabled recombinant wild-type tau of isoform 0N4R to spontaneously polymerize …
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Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias
… the molecular mechanisms underlying human tauopathies, with an emphasis on Alzheimer’s disease (AD)—the most prevalent and well-characterized tauopathy. Pathological tau species are among the earliest inclusions observed in post-mortem brains of individuals with dementia and strongly …
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The role of the type-I interferon response in the aggregation of tau protein
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative diseases characterised by the abnormal intracellular inclusions of hyperphosphorylated tau protein in neurons and/or glia. In AD, tau protein aggregation is accompanied by extracellular plaques of β-amyloid (Aβ) protein, protein …
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A molecular analysis of the relation between TDP-43 and tau pathology
… associated protein found in inclusions in tauopathies including Alzheimer's disease. One known cause of neurodegeneration is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor Protein (APP) …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and …
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Inhibition of Alzheimer’s type toxic aggregates of tau with fungal secondary metabolites
… themselves in the varying pathologies of tauopathies. Tau aggregation in a common mode of pathogenesis in tauopathies, including Alzheimer's disease. Tau aggregation correlates with dementia and neurodegeneration and is viewed as a potential therapeutic target for AD. Fungi have …
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Disease-modifying effects of human small heat shock proteins in zebrafish models of neurodegeneration
… proteins and degeneration of brain structures. Tauopathies are a collective of >20 such diseases featuring abnormally aggregating tau, a microtubule-associated protein normally acting to stabilise these protein cargo tracks. There is currently no cure. Small heat shock proteins (sHSPs) are …
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Mechanistic Investigation into the Regulation of Amyloid Motifs in Tau Aggregation and Disease
… neurodegenerative diseases, collectively called tauopathies. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but the molecular mechanism of how they promote tau assembly into amyloids is poorly understood. Many …
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Topology and geometry-based methods for quantifying the complexity of protein structures
… in a class of neurodegenerative diseases, called tauopathies. The methods developed in this dissertation are general and applicable to other proteins as well as any physical systems of filaments. By using topological measures (Linking Number, Writhe and second Vassiliev measure) to quantify …
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Lessons from Tau RT–QuIC: Structure, Kinetics, and Drug Discovery
… neurodegenerative diseases collectively known as tauopathies. This group encompasses over 20 clinicopathological conditions, including Alzheimer’s disease (AD), which accounts for about 70% of dementia cases worldwide. Cryo–EM studies of amyloid filaments isolated from human brains have revealed …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… inclusions in a diverse class of diseases called tauopathies. A growing body of biochemical and structural literature has now confirmed that tau takes different disease-specific aggregate conformations, which then propagate throughout the brains of afflicted patients. The disease-specific …
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The Effects of Treadmill Exercise in the P301S Mouse Model of Tau Pathology
Tauopathies are a group of neurodegenerative disorders characterized by severe cognitive and motor deficits that are associated with the development of neurofibrillary tangles (NFTs), intracellular protein aggregates composed of hyperphosphorylated tau (a microtubule associated protein). The …
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Mechanisms of Adsorption and Surface-Mediated Aggregation of Intrinsically Disordered Protein Tau at Model Surfaces
… diseases, commonly referred to as tauopathies. In its native state, the protein tau’s function is to promote the assembly, and aid in the stabilization of microtubules. The microtubules allow for material transport through the axon, to and from the neuron. While the presence of …
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