Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"Tau protein"”.
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Development of electrochemical immunosensors for detection of Tau protein : computational and experimental studies
Submitted in fulfilment of the Degree of Master of Applied Sciences in Chemistry, Durban University of Technology, Durban, South Africa, 2019.
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… (NFT) composed of the microtubule stabilizing protein Tau are a pathological hallmark of Alzheimer's disease (AD) and many other dementia related diseases specified as Tauopathies. Due to alternative mRNA splicing, intrinsically disordered Tau exists as six separate isoforms in the adult human …
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Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
The accumulation of intraneuronal aggregated tau protein underlies many common neurodegenerative diseases and is a key target in therapeutic development. Whilst promising in pre-clinical models, tau targeting antibodies have performed poorly in clinical trials, potentially due to low target …
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The role of the type-I interferon response in the aggregation of tau protein
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative diseases characterised by the abnormal intracellular inclusions of hyperphosphorylated tau protein in neurons and/or glia. In AD, tau protein aggregation is accompanied by extracellular plaques of β-amyloid (Aβ) protein, protein …
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Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases
Tau protein is the primary constituent of protein aggregates known as neurofibrillary tangles, a pathological hallmark of Alzheimer's disease (AD). Previous studies suggest that tau protein may play a contributing role in neurodegenerative diseases such as AD. Thus characterizing the structural …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
A protein's sequence of amino acids determines how it folds. That folded structure is linked to protein function, and misfolding to dysfunction. Protein misfolding and aggregation into β-sheet rich fibrillar aggregates is connected with over 20 neurodegenerative diseases, including Alzheimer's …
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On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
Tau is a multifaceted and dynamic protein vital to a number of physiological processes, notably in the architecture of the cytoskeleton. Its key role in the assembly and stabilisation of microtubules, which are critical for molecular shuttling and axonal growth, underscores the significance of tau …
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Cross-Seeding Potential of Misfolded Amyloid-Beta Strains On Tau Protein: Examining The Puzzle Pieces of Alzheimer'S Disease
… (Aβ) and the intraneuronal buildup of tau neurofibrillary tangles (NFTs). Compelling evidence suggests that Aβ triggers tau accumulation. Both of these disease-associated proteins are known to contribute to the typical AD associated clinical signs. Interestingly, these proteins have …
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Transthyretin-, Aß 1-40- und Aß 1-42- und Tau-Protein-Konzentrationen im Liquor cerebrospinalis bei demenziellen Erkrankungen
… cerebrospinalis Spiegel von Transthyretin, Tau-Protein sowie der beta-Amyloidpeptide 1-42 und1-40 bei 106 Patienten mit unterschiedlichen Demenzerkrankungen wie Alzheimer-Demenz, Creutzfeldt-Jakob-Krankheit, Lewy-Körperchen-Demenz, frontotemporale Demenz und Normaldruckhydrozephalus im …
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UNDERSTANDING THE PATHOLOGICAL EFFECTS OF EXOGENOUS MONOMERIC TAU PROTEIN AND THE DEVELOPMENT OF NOVEL TREATMENTS FOR ALZHEIMER’S DISEASE
Microtubule-associated protein tau (tau) is known to play a role in Alzheimer’s disease (AD) through pathways resulting in the gradual formation of neurofibrillary tangles. The uptake of monomeric tau from the extracellular medium, and its aggregation at low pH inside of neurons has previously been …
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Mechanisms of Adsorption and Surface-Mediated Aggregation of Intrinsically Disordered Protein Tau at Model Surfaces
… of an intrinsically disordered soluble protein, tau, into insoluble filaments is a defining hallmark of many neurodegenerative diseases, commonly referred to as tauopathies. In its native state, the protein tau’s function is to promote the assembly, and aid in the stabilization of …
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… disease 3 D. Normal functions of tau protein 4 E. Structure and Posttranslational Modifications of the Tau Protein 5 F. Distribution of tau phosphorylation sites and NFT formation in AD brains 7 G. Monoclonal antibody AT8 recognizes tau phosphorylation 11 H. Cholinergic dysfunction …
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Computer Simulation of Biological Systems
… surface; (b) the dynamical modelling of protein tau, an intrinsically disordered protein. We briefly describe here the two problems; for their detailed introduction we refer respectively to chapter DNA and chapter TAU. The interest in the study of the adsorption of DNA on functionalized …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
Tauopathies refer to neurodegenerative disorders characterized by the presence of abnormal aggregates of Tau protein, leading to the formation of neurofibrillary tangles (NFTs) within neuronal cells. Tau, a protein associated with microtubules (MTs), plays a crucial role in regulating the dynamics …
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Mechanisms of Regulation of Tau Ires Mediated Translation
… It was previously shown that the 5’ UTR of the tau mRNA contains an IRES. In this study I show that IRES dependent translation of tau IRES is regulated at multiple levels in order to regulate the expression of the tau protein.</p> <p>Tau protein is ubiquitously expressed but is concentrated in …
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Characterization of Tau Oligomeric Strains: Implications for Disease Phenotypes
… are commonly characterized by the aggregation of tau protein. While original studies of Alzheimer’s disease noted the presence of tau aggregated into large, insoluble fibrillar structures known as neurofibrillary tangles, our lab and others found that small, oligomeric aggregates are likely the …
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… AD pathogenesis, i.e. Amyloid-beta peptide and tau protein, on hippocampal synaptic plasticity and memory in animal models. After reviewing the pathophysiological models that have been developed so far, our general purpose was to study novel aspects of Amyloid-beta peptide and tau involvement in …
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Detection of dementia (Alzheimer’s disease) marker tau using a four gold microband electrode impedance sensor
… biosensor system for the detection of tau protein, which is one of the most sensitive markers for the prediction of Alzheimer’s and the level of this marker in the plasma has been found to correlate with cerebro-spinal fluid (CSF) load. The biosensor is based on the formation of stable …
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