Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Tau pathology"”.
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Tau pathology, microglia activation, and network dysfunction in Alzheimer’s disease
Tau pathology and neuroinflammation are key etio-pathogenetic mediators of Alzheimer’s disease (AD). Network dysfunction has also been reported in AD and linked to cognitive impairment. However, it is unclear how tau pathology and neuroinflammation contribute to network dysfunction and cognitive …
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A molecular analysis of the relation between TDP-43 and tau pathology
Tau is a microtubule associated protein found in inclusions in tauopathies including Alzheimer's disease. One known cause of neurodegeneration is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor …
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The Effects of Treadmill Exercise in the P301S Mouse Model of Tau Pathology
Tauopathies are a group of neurodegenerative disorders characterized by severe cognitive and motor deficits that are associated with the development of neurofibrillary tangles (NFTs), intracellular protein aggregates composed of hyperphosphorylated tau (a microtubule associated protein). The …
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The Effect of Traumatic Brain Injury On Tau Pathology By A Potential Seeding Mechanism
… (PMDs). The microtubule associated protein tau is known to form insoluble filaments known as neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau (pTau) found in a subset of PMDs called tauopathies, such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE), …
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Characterizing Medial Temporal Lobe Neurodegeneration Due To Tau Pathology In Alzheimer's Disease Using Postmortem Imaging
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). Using in vivo structural magnetic resonance image (MRI) analysis, volumetric change in the MTL caused …
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The Genetic Basis Of Neurodegenerative Diseases: The Role Of Sel1L In Tau Pathology And Neuropathology
… elevated levels of phosphorylated microtubule tau protein (p-tau), a pathological characteristic of many neurodegenerative diseases. Our data suggest that a brachial downstream gene of UPR, c-Jun N-terminal kinases (JNK), might be the major tau kinase that induces tau phosphorylation in …
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Investigating the Use of [18-F] tau-PET Imaging as a Biomarker of tau Pathology in Retired Athletes at Risk of Neurodegeneration
… is characterized by abnormal accumulation of tau protein in the brains of affected athletes in a pattern distinct from other neurodegenerative diseases. There is currently no in vivo biomarker of tau pathology of chronic traumatic encephalopathy, and the diagnosis is made post-mortem. [18-F] …
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Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
… associated with Alzheimer’s disease pathology based on the presence of e4, we compared individuals with and without the APOE e4 allele within a community based aging cohort (n = 186). Cellular density of Iba1, a marker of microglia, was positively associated with tau pathology as …
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The role of the type-I interferon response in the aggregation of tau protein
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative diseases characterised by the abnormal intracellular inclusions of hyperphosphorylated tau protein in neurons and/or glia. In AD, tau protein aggregation is accompanied by extracellular plaques of β-amyloid (Aβ) protein, protein …
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Cofilin-actin rods: quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway
… tangles composed mainly of hyperphosphorylated tau protein, are used for post-mortem confirmation of the diagnosis of Alzheimer's disease (AD). However, a shift in disease hypothesis has changed over the years. It is now generally accepted that soluble forms of Aβ oligomers and not fibrils, …
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The role of tau and neuroinflammation in Progressive Supranuclear Palsy and Alzheimer's Disease
… ability to assess the distribution and extent of tau pathology and neuroinflammation in Progressive Supranuclear Palsy (PSP) and Alzheimer’s disease (AD) ‘in vivo’ and to validate it using post mortem data is critical to develop reliable biomarkers for these disorders, and for tracking the effects …
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UNDERSTANDING THE PATHOLOGICAL EFFECTS OF EXOGENOUS MONOMERIC TAU PROTEIN AND THE DEVELOPMENT OF NOVEL TREATMENTS FOR ALZHEIMER’S DISEASE
Microtubule-associated protein tau (tau) is known to play a role in Alzheimer’s disease (AD) through pathways resulting in the gradual formation of neurofibrillary tangles. The uptake of monomeric tau from the extracellular medium, and its aggregation at low pH inside of neurons has previously been …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… tangles: NFTs) composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury: TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in …
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Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
… filaments (PHFs) of the hyperphosphorylated tau protein, along with synaptic loss and neuronal death. There are numerous biochemical mechanisms involved in AD pathogenesis, however the reigning hypothesis points to toxic oligomeric Aβ species as the primary causative factor in a cascade of …
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A streptozotocin-induced model of Alzheimer's disease in mice with wild-type human tau
… Association, 2012). Hyperphosphorylation of tau, the main component of neurofibrillary tangles observed in AD, leads to deficits in cell structure and function. Because recent data suggest impairments in cerebral glucose utilization and energy metabolism play a prominent role in the …
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Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
… These are usually associated with either tau or TDP-43 pathology, with highly variable clinicopathological correlations. Neuroinflammation also contributes to the pathogenesis of FTD, but its relevance to the disease spectrum is incompletely understood. There is a critical need for better …
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Predictors of Chronic Traumatic Encephalopathy in NFL Players: A Meta Analysis Review
… many pathological changes and an emergence of tau pathology, all of which can lead to presentation with cognitive dysfunction, behavioral changes, and further motor decline in the later stages. After passing the inclusion criteria, a meta-analysis comprising four articles was computed using …
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