Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Tau aggregation"”.
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Tau Aggregation, Conformational Selection, and Inhibition
<p>Tau fibrils are a pathological hallmark of over 20 neurodegenerative disorders, including Alzheimer's disease. There currently is no cure for these diseases and treatments are limited. Once Tau fibrils form in the brain, they propagate down neuronal networks, and this spreading is linked to …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
… aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3b or …
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The Role of DnaJC7 in Modulating Tau Aggregation in the Cell
Appendix A contains a previously published manuscript, which is referenced below as a related citation.
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Targeting Tau Aggregation for the Diagnosis and Treatment of Alzheimer’s Disease
The aggregation of tau protein in the brain is a defining pathological characteristic of several diseases, known as tauopathies, the most common of which is Alzheimer’s disease. Because the temporal and spatial progression of tau lesions correlates with neurodegeneration and cognitive decline, they …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
… by the presence of intracellular abnormal aggregation of α-Synuclein (α-Syn) in Lewy bodies (LBs) and Lewy neurites (LNs), are collectively known as synucleinopathies. Even so, tau protein pathology is abundantly found in these diseases. Apart from Parkinson’s disease (PD), dementia with …
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Mechanistic Investigation into the Regulation of Amyloid Motifs in Tau Aggregation and Disease
Amyloid formation of tau protein is a unifying theme in a multitude of neurodegenerative diseases, collectively called tauopathies. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but the molecular mechanism of how they …
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… composed of the microtubule stabilizing protein Tau are a pathological hallmark of Alzheimer's disease (AD) and many other dementia related diseases specified as Tauopathies. Due to alternative mRNA splicing, intrinsically disordered Tau exists as six separate isoforms in the adult human brain …
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Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
Tau neurofibrillary tangles or aggregates are a common neuropathological feature found in a number of neurodegenerative conditions, including Alzheimer's disease. Understanding the kinetics of this aggregate build up, how it varies across patients, and how aggregation might be influenced by …
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Inhibition of Alzheimer’s type toxic aggregates of tau with fungal secondary metabolites
Tau is a microtubule-associated protein that is typically found in the axons of neurons. The aggregation of the tau is a significant event in many neurodegenerative diseases including Alzheimer's disease. In these disease tau dissociates from microtubules and begins to form toxic insoluble …
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Assay Development for Tau-directed Therapeutics
… comprised of the microtubule-associated protein tau. These insoluble aggregates are found in the brain of those affected by Alzheimer’s disease and other related tauopathies. Advancements in cryo-electron microscopy over the last few years have revealed that structures of these aggregates found …
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The role of the type-I interferon response in the aggregation of tau protein
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative diseases characterised by the abnormal intracellular inclusions of hyperphosphorylated tau protein in neurons and/or glia. In AD, tau protein aggregation is accompanied by extracellular plaques of β-amyloid (Aβ) protein, protein …
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Single-molecule profiling of tau aggregates in tauopathies: From test tube to patient
… very low concentrations. A notable example are tauopathies, a group of neurodegenerative diseases in which pathological aggregation of the tau protein plays a central role. Current approaches often fail to resolve the small, early-stage tau aggregates that are believed to be a major neurotoxic …
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Using biological and chemical information to improve understanding of drug mechanism of action on the systems-level
… information to generate MoA hypotheses for the tau aggregation inhibitor Anle138b. By using both chemical structure and transcriptomics information, along with causal reasoning, pathway enrichment and machine learning-based target prediction, we were able to generate hypotheses across multiple …
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Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
The accumulation of intraneuronal aggregated tau protein underlies many common neurodegenerative diseases and is a key target in therapeutic development. Whilst promising in pre-clinical models, tau targeting antibodies have performed poorly in clinical trials, potentially due to low target …
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Engineering the antibody-TRIM21 interface for the improved intracellular clearance of pathogenic targets
… hallmark of AD is the accumulation of misfolded tau protein deposits inside neurons and glia. Current therapies provide only modest clinical benefit and do not directly target tau, which is a key pathogenic driver in AD and other primary tauopathies, for which no disease-modifying treatments …
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Mechanisms of Adsorption and Surface-Mediated Aggregation of Intrinsically Disordered Protein Tau at Model Surfaces
The adsorption and aggregation of an intrinsically disordered soluble protein, tau, into insoluble filaments is a defining hallmark of many neurodegenerative diseases, commonly referred to as tauopathies. In its native state, the protein tau’s function is to promote the assembly, and aid in the …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
Tauopathies refer to neurodegenerative disorders characterized by the presence of abnormal aggregates of Tau protein, leading to the formation of neurofibrillary tangles (NFTs) within neuronal cells. Tau, a protein associated with microtubules (MTs), plays a crucial role in regulating the dynamics …
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On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
Tau is a multifaceted and dynamic protein vital to a number of physiological processes, notably in the architecture of the cytoskeleton. Its key role in the assembly and stabilisation of microtubules, which are critical for molecular shuttling and axonal growth, underscores the significance of tau …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and …
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UNDERSTANDING THE PATHOLOGICAL EFFECTS OF EXOGENOUS MONOMERIC TAU PROTEIN AND THE DEVELOPMENT OF NOVEL TREATMENTS FOR ALZHEIMER’S DISEASE
Microtubule-associated protein tau (tau) is known to play a role in Alzheimer’s disease (AD) through pathways resulting in the gradual formation of neurofibrillary tangles. The uptake of monomeric tau from the extracellular medium, and its aggregation at low pH inside of neurons has previously been …
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