Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Tau Oligomers"”.
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Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias
… the molecular mechanisms underlying human tauopathies, with an emphasis on Alzheimer’s disease (AD)—the most prevalent and well-characterized tauopathy. Pathological tau species are among the earliest inclusions observed in post-mortem brains of individuals with dementia and strongly …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and …
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Characterization of Tau Oligomeric Strains: Implications for Disease Phenotypes
… are commonly characterized by the aggregation of tau protein. While original studies of Alzheimer’s disease noted the presence of tau aggregated into large, insoluble fibrillar structures known as neurofibrillary tangles, our lab and others found that small, oligomeric aggregates are likely the …
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Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
… synaptic sensitivity to amyloid beta (Aβ) and tau, thus contributing to the cognitive decline that characterizes this neurodegenerative disorder. Considering this, I used male Sprague-Dawley rats that underwent a lateral fluid percussion injury (FPI) at acute (2 and 7 days post-injury), …
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p53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's Disease
… all controlled by p53. Here, we show p53 forms oligomers and fibrils in human AD brain, but not control brain. p53 oligomers can also be detected in htau, P301L, and Tg2576 mouse models. Additionally, we demonstrate that p53 interacts with tau, specifically tau oligomers, in AD brain and can be …
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Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology
… beta (Aβ). Recently, the co-presence of Aβ oligomers (Aβo) and tau oligomers (tau-o) at the synapses has been suggested to exacerbate this dysfunction. Therefore, the development of therapeutics aimed at protecting the synapses from the toxic binding of both proteins at the synapses can …
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Connectivity biomarkers in neurodegenerative tauopathies
The primary tauopathies are a group of neurodegenerative diseases affecting movement and cognition. In this thesis I study Progressive Supranuclear Palsy (PSP) and the Corticobasal Syndrome (CBS), two parkinsonian disorders associated with accumulation of hyperphos- phorylated and abnormally folded …
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On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
Tau is a multifaceted and dynamic protein vital to a number of physiological processes, notably in the architecture of the cytoskeleton. Its key role in the assembly and stabilisation of microtubules, which are critical for molecular shuttling and axonal growth, underscores the significance of tau …