Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 623 for “"Tau"”.
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… composed of the microtubule stabilizing protein Tau are a pathological hallmark of Alzheimer's disease (AD) and many other dementia related diseases specified as Tauopathies. Due to alternative mRNA splicing, intrinsically disordered Tau exists as six separate isoforms in the adult human brain …
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A systematic resolution study of [tau][tau] decays at CMS at the LHC
… I perform a systematic resolution study for di-tau pairs at the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) at CERN. I performed this analysis using Monte Carlo simulated events with a Higgs boson which decays into two tau particles with initial mass mH = 90 - 500 …
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Higgs pair production in [beta][beta][tau][tau] final states at the HL-LHC
… model Higgs pair production in [beta][beta][tau][tau] final states at the High Luminosity LHC is investigated. Higgs pair production can be used to measure the Higgs trilinear coupling constant, which uniquely determines the shape of the Higgs potential. The doubly hadronic, hadron-muon, and …
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Investigating tau propagation in situ
The abnormal assembly of tau protein in neurons is the pathological hallmark of multiple neurodegenerative diseases, including Alzheimer’s disease (AD). In AD, tau assembly begins in the locus coeruleus and transentorhinal cortex, and progresses over years to connected regions in the limbic system …
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Kitiaga mo fakamahani e hikihikiaga matagi he tau fifine Niue: tau pūhala he tau hiapo Niue women’s perspectives and experiences of climate change: a hiapo approach
Indigenous communities in the Pacific are on the front-line of some of the most severe climate change impacts. Pacific leaders have consistently stated the urgent need for climate action (Pacific Islands Forum Secretariat, 2019) and fought for larger emitting nations to be more accountable for …
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Assay Development for Tau-directed Therapeutics
… comprised of the microtubule-associated protein tau. These insoluble aggregates are found in the brain of those affected by Alzheimer’s disease and other related tauopathies. Advancements in cryo-electron microscopy over the last few years have revealed that structures of these aggregates found …
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Connection Problem for Painlevé Tau Functions
… the differential identities for isomonodromic tau functions, describing their monodromy dependence. For Painlev´e equations we obtain them from the relation of tau function to classical action which is a consequence of quasihomogeneity of corresponding Hamiltonians. We use these identities to …
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Tau Aggregation, Conformational Selection, and Inhibition
<p>Tau fibrils are a pathological hallmark of over 20 neurodegenerative disorders, including Alzheimer's disease. There currently is no cure for these diseases and treatments are limited. Once Tau fibrils form in the brain, they propagate down neuronal networks, and this spreading is linked to …
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Amplitude balancing in [tau]-p domain
An approach to balance the amplitude of seismic data in the Ï -Ï domain is introduced in this study. The idea of amplitude balancing technique is based on the following observation: In the Ï -Ï domain, direct wave, ground-roll, primary reflection, multiple and refraction arrivals are located at …
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Antisense Reduction of the Protein Tau Attenuates Neuronal Hyperexcitability and Permits Clearance of Intraneuronal Tau Accumulations in vivo
<p>The protein tau is a major contributor in some of the most prevalent neurodegenerative diseases, including the most common form of dementia, Alzheimer's Disease (AD). As a member of the microtubule-associated protein family, tau in enriched in the axons of mature and growing neurons, though …
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Measurement of Tau Neutrino Appearance and Charged-current Tau Neutrino Cross Section with Atmospheric Neutrinos in Super-Kamiokande
… neutrino data for more than 20 years. Tau neutrino appearance is expected in atmospheric neutrinos due to neutrino oscillations. The wide span of neutrino energies and neutrino path lengths in atmospheric neutrinos and the large target mass of Super-Kamiokande allow a detection of …
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Testing Lepton Nonuniversality In Tau Neutrino Scattering
… the neutrino deep inelastic scattering processes tau neutrino+nucleon to tau + X and muon neutrino+nucleon to muon + X where we assume the largest new physics effects are in the tau sector. We also consider an explicit leptoquark model in our calculations. In order to make comparison with the …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
… aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3b or …
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Study of Michel spectrum of tau decay
… to examine weak couplings through leptonic [tau] decay. I will use the ratio of Br... and Br... and the Michel parameters [rho] and [eta]. which describe the momenta spectrum of the daughter leptons. I studied using a simultaneous fit to the [tau] --> e and [tau] --> [mu] momentum spectra, …
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Inhibition of tau kinase activity by ATP
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias
… the molecular mechanisms underlying human tauopathies, with an emphasis on Alzheimer’s disease (AD)—the most prevalent and well-characterized tauopathy. Pathological tau species are among the earliest inclusions observed in post-mortem brains of individuals with dementia and strongly …
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Mechanisms of Regulation of Tau Ires Mediated Translation
… It was previously shown that the 5’ UTR of the tau mRNA contains an IRES. In this study I show that IRES dependent translation of tau IRES is regulated at multiple levels in order to regulate the expression of the tau protein.</p> <p>Tau protein is ubiquitously expressed but is concentrated in …
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Characterisation of Tau splicing factors in Alzheimer’s disease
… tangles consist of hyperphosphorylated tau, one of the pathological hallmarks of Alzheimer’s disease (AD). Alternative splicing of the tau pre-mRNA produces six tau isoforms with or without exon 10 (E10); tau4R or tau3R, microtubule binding repeats respectively. In normal human brains …
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