Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Targeting signals"”.
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Tissue targeting signals of Tomato leaf curl virus
The tissue and intracellular distribution of the monopartite Tomato leaf curl virus (TLCV) was investigated by in situ hybridization. contrary to the previous understanding of geminiviral localization, single stranded (SS) DNA of TCLV accumulated in the cytoplasm. TCLV ssDNA was also found in the …
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Distinct C-terminal Amino Acid Sequence Motifs Serve as the Targeting Signals for Outer Mitochondrial Membrane and Plastid Outer Envelope TA Proteins
… and characterising distinct, C-terminal targeting motifs responsible for the proper sorting of at least a subset of these proteins. Collectively, the results of this thesis provide important insight into the molecular mechanisms that underlie the biogenesis of TA proteins in plant cells.
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Axon/dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy Terminal Domains
The subcellular targeting of neurotransmitter receptors is vital in controlling polarized information flow in the brain. We show here that metabotropic glutamate receptors are differentially targeted when expressed from defective viral vectors in cultured hippocampal neurons: group I mGluR1a and …
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The Translocase of the Outer Membrane of Mitochondria (TOM complex)
… in the mitochondrial outer membrane, mediates targeting and membrane translocation of virtually all nuclear-encoded mitochondrial preproteins analyzed so far. In the present study the mechanisms by which the TOM complex recognizes different precursor proteins and translocates them across the …
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The importance of N-linked glycosylation on the N-domain of angiotensin-I converting enzyme
… modulation of the immune response, and providing targeting signals. Glycosylation is required for the expression of active ACE and structural studies of ACE have been fraught with severe difficulties because of surface N-glycosylation of the protein. This problem has been addressed to a large …
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Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
… systems, codon optimisations and subcellular targeting. (Maclean et al., 2007; Yang et al., 2005). The latter sometimes results in unexpected locations which might reflect on an inherent property of the protein itself or specifically be associated with the plant organ involved (Chikwamba et …
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Recognition Mechanisms of Nuclear Localization and Export Signals
… putative proline-tyrosine nuclear localization signals which were validated through biochemical studies. Additionally, one of the proteins identified, Tfg2p, was verified as a bona fide Karyopherin 104 substrate. Analysis of Tfg2p's cellular localization revealed that its nuclear localization …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… These results suggest that outside mechanical signals can be differently translated inside cells through different interactions between specific extracellular molecules and integrin subtypes. In summary, this thesis can advance our in-depth understanding on how Src/FAK signaling is regulated at …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
… dependent on the presence of specific organellar targeting signals. Silencing of total TbAK expression in the procyclic form of T. brucei resulted in a significant growth defect, and was even lethal in the presence of the oxidative challenging agent hydrogen peroxide. These results suggest an …
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Eine Untersuchung zur Endozytose in Pflanzenzellen
… the functionality of mammalian endocytosis signals in plant cells and indicates that the prerequisites for receptor-mediated endocytosis in plant cells exist. Furthermore, relocation of both fusion proteins to the cell plate during cytokinesis suggests that also the targeting signals within …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… role(s) of their N-terminal presequences (matrix targeting signals) in the regulation of protein expression/folding. A variety of precursor constructs of human PDC were engineered to carry out this work. Thus, pre-E2, its N-terminal truncated form and pre-E3BP containing elongated presequences …