Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 5345 for “"Targeting"”.
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Targeting adrenomedullin in sepsis
Contains fulltext : 201197.pdf (Publisher’s version ) (Open Access)
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Nanoparticles Targeting at Inflammation Site
This thesis presents the development and translational evaluation of advanced nanoparticle-based drug delivery systems designed for the sustained and localized delivery of hydrophobic therapeutics, with a focus on pazopanib. Addressing key challenges in drug solubility, stability, and scalable …
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Targeting Nanoparticles to Tumor Vasculature
Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use escape mechanisms against chemotherapeutic agents as frequently as tumor cells …
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TARGETING THE NRF2/KEAP1 INTERACTION
The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory pathway. The transcription factor Nrf2 has been found to be a key mediator in the resolution of inflammation and the progression of chronic diseases. Most known inducers of the Nrf2 …
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Targeting mutant p53 in cSCCs
… have investigated the potential of targeting mutant p53 for cSCC therapy and mechanisms that promote mutant p53 accumulation in cSCCs. We selected low-passage cSCC cell lines that express hotspot mutant p53 proteins, in cSCCs and in general, by analysing TP53 mutational data from the …
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Targeting c-Met for therapy
c-Met is a tyrosine receptor kinase which is activated by its only ligand, the hepatocyte growth factor (HGF). Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met and HGF knock-out mice are …
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Targeting Cyclin T1 in Cancer
[Restricted]
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Targeting Vasculogenic Mimicry in Cancer
Like any tissue, tumours depend on a constant blood supply to deliver oxygen and nutrients. Tumour neovascularization is achieved most frequently through the process of angiogenesis, in which tumour cells secrete extracellular factors to recruit host endothelium to grow into the neoplastic tissue. …
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Receptor mediated targeting of liposomes
The targeting of liposomes to cells and the delivery of the liposomal contents into the cells have been investigated using either α-melanocyte stimulating hormone or Ricin-B-chain as ligands for promoting the binding of liposomes to cells. α-melanocyte stimulating hormone has been conjugated to …
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Optimal Targeting under Gender Fairness
While targeted marketing campaigns can offer high potential for increased firms’ profit, they often lack due consideration for fairness among different protected demographic groups. We investigate methods to mitigate gender disparities for both firm’s actions and benefit outcomes in the setting of …
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Proteolysis-targeting chimeras as a novel strategy for targeting epigenetic mechanisms in Plasmodium falciparum parasites
… We therefore proposed the use of Proteolysis-targeting chimeras (PROTACs) that can induce the degradation of a target protein via the cells ubiquitin-proteasome system rather than inhibiting it. Ideally, for PROTACs to be effective in malaria research, they should bind to essential proteins, …
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Targeting Cholinergic Neuromodulation in Stroke Recovery
After ischemic stroke, patients can have significant deficits that limit their daily function. Most patients experience some degree of spontaneous recovery in the weeks after stroke. However, this recovery is often incomplete, and there are no treatment approaches which have been established to …
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Distribution and targeting of CLC-3
ClC-3 is a ubiquitously expressed chloride channel that is present in synaptic vesicles and endosome/lysosome compartments. The channel is largely intracellular, but has been observed at the plasma membrane as well. The aim of this study was to identify the trafficking pathway for delivery of ClC-3 …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the exploration of the immune background of GBC, and the establishment of a CCA mouse model mimicking mutation profiles of CCA patients.</p> …
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Targeting Traf6 For Cancer Therapeutical Development
<p>Tumor necrosis factor (TNF)-Receptor Associated Factors (TRAFs) are a family of signal transducer proteins. TRAF6 is a unique member of this family in that it is involved in not only the TNF superfamily, but the toll-like receptor (TLR)/IL-1R (TIR) superfamily. The formation of the complex …
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
<p>Over the last century, the use of antibiotics has enabled many advances in modern medicine, making life as we know it possible. In recent years, however, emerging bacterial resistance to virtually all major antibiotic classes has resulted in a worldwide increase in morbidity, mortality, and …
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Targeting Natural Supersymmetry With Top Quarks
This thesis describes a search for natural supersymmetry via the production of light top squarks (stops) with the ATLAS experiment, using 13 TeV proton-proton collision data delivered by the Large Hadron Collider. A range of models is considered where the stop may decay to top quarks, b jets, and a …
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