Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Targeted proteomics"”.
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Study of the cell cycle interactome of Arabidopsis thaliana through a targeted proteomics approach
Defining protein complexes is critical to virtually all aspects of cell biology, because many cellular processes are regulated by stable protein complexes and their identification often provides insights into their function. In the introduction of the thesis, an overview is given on proteomic …
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… human endogenous protein quantification using targeted quantitative proteomics has increased. These quantification measurements are useful in many aspects of drug discovery and development, including protein biomarker monitoring, the development of a more accurate physiological-based …
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Global and targeted proteomics in Arabidopsis thaliana: A study of secondary metabolism and phytohormone signaling
Proteomics is defined as a tool to explore how proteins control and regulate important molecular and physiological processes. Further, peptide-centric approaches, or bottom-up methods, provide more comprehensive coverage of a proteome compared to whole-protein approaches. This body of work assesses …
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Characterizing blood plasma proteins from organ tissue in rainbow trout (Oncorhynchus mykiss) using a non-targeted proteomics approach
Protein expression patterns adapt to various cues to meet the needs of an organism. The dynamicity of an organism’s proteome can therefore reveal information about an organism’s health. Proteome databases contain limited information regarding organisms outside of medicinal biology. The Uniprot …
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Investigation of ocular drug metabolism and pharmacokinetics using multi-omics and in-situ microdialysis
… by integrating comparative transcriptomics, targeted proteomics, functional enzymatic activity, and in vivo ocular pharmacokinetic characterization in rabbit tissues.
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Identification of Novel Fluid Biomarkers for Alzheimer's Disease
… the cerebrospinal fluid: CSF) using an unbiased proteomics approach: two-dimensional difference gel electrophoresis with liquid chromatography tandem mass spectrometry). From this, we identified 47 proteins that differed in abundance between cognitively normal: Clinical Dementia Rating [CDR] 0) …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… samples using state of the art mass spectrometry proteomics identified dysregulation of one-carbon metabolism in NASH. This dissertation details the molecular mechanisms for how these proteomic changes can drive NASH pathogenesis and be targeted for therapeutic purposes. Chapter 1 provides an …
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Mining common genetic Variants impacting on Allele-Specific Translation and cancer risk
… variant to provide a proof of concept for using proteomics approaches to measure allele-specific differences in protein expression in cells heterozygous for a nonsynonymous variant. Interestingly, targeted proteomics using synthetic isotope-labeled peptides confirmed a pronounced imbalance …