Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Targeted liposomes"”.
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Selective delivery of arsenic trioxide to HPV positive cervical cancer cells with targeted liposomes
… cancer treatment. The size and surface charge of liposomes were optimised and 100nm neutral liposomes demonstrated maximum stability, least intrinsic toxicity and highest loading efficiency among all the tested formulations. Furthermore, both free and chosen liposomal-ATO were exposed to two …
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FOLATE RECEPTOR TARGETED LIPOSOMES AS THE ENABLING TECHNOLOGY FOR THE DELIVERY OF CHEMOTHERAPEUTICS IN THE TREATMENT OF OVARIAN CANCER
Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could …
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Targeting Nanoparticles to Tumor Vasculature
… targeting to tumor vessels. Nanoparticles, and liposomes in particular, are extremely versatile because they can be adapted to carry drugs, imaging agents, or energy capture agents. In my project, I have constructed liposomes targeted to three molecules identified as tumor vascular markers: …
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Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel
… demonstrated by tumor cells. Newer targeted delivery systems with more specificity for gliomas, improved safety profiles, and an enhanced ability to permeate through the BBB are actively under development as the next generation glioma therapies. <br /><br />Blood brain barrier and …
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Design, Development, Characterization and Testing of CD22 Targeted Long Circulating Liposomal Drug Delivery Systems for B Cell Malignancies
… damage caused to cardiomyocytes by doxorubicin. Targeted delivery of AD 198 is crucial to moderate the non-specific interactions of the chemotherapeutic agent with healthy cells. The objective of this work was to design, develop and evaluate AD 198 loaded liposomal formulations for targeted …
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Methods for Identifying Subcellular Targeting Ligands and Selected Applications
… ligand for a novel immunotherapy. H1299.3 targeted liposomes facilitate delivery of antigenic peptide specifically in MHC class 1 molecules of cancer cells resulting in activation of secondary immune response against the cancer cells. Thus, we present two novel methods for identify …
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Receptor mediated targeting of liposomes
The targeting of liposomes to cells and the delivery of the liposomal contents into the cells have been investigated using either α-melanocyte stimulating hormone or Ricin-B-chain as ligands for promoting the binding of liposomes to cells. α-melanocyte stimulating hormone has been conjugated to …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
… peptide targeting of liposomal doxorubicin. Liposomes displaying the higher affinity multivalent H2009.1 tetrameric peptide demonstrated higher specificity and greater toxicity towards αᵥβ₆-expressing cells than liposomes displaying the lower affinity monomeric H2009.1 peptide. All H2009.1 …
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Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
… surface charge on the LNPs we redirected liver targeted liposomes to lung endothelial cells. Examination of the plasma proteins bound to the LNPs revealed apolipoprotein (Apo) B and ApoE attached to the hepatocellular targeted LNPs, with serum albumin and fibrinogen were bound to the lung …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… pathological events. In drug targeting research, liposomes are considered as versatile for their ability to carry drug payloads and flexible enough to modulate their surface for targeting purposes. In the current investigation, I developed surface modified stable liposome formulation for delivery …