Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 198 for “"Targeted Therapy"”.
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Targeted therapy: strategie innovative per approcci teranostici
Negli ultimi anni, l’oncologia ha compiuto notevoli progressi, principalmente grazie all’impiego di approcci multidisciplinari, che hanno rinnovato la medicina di precisione nella ricerca di terapie personalizzate e metodi diagnostici all’avanguardia. Tra queste, le modalità radioterapeutiche non …
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Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy
… improve prognostication and personalization of therapy for women diagnosed with metastatic breast cancer. By analysis of tumor biopsies collected at different stages of disease progression, we showed that, in general, the phenotype of the primary tumor is typically conserved during tumor …
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Engineering nanomaterials for molecular imaging and targeted therapy
… associated with molecular profiling and targeted drug delivery. The first goal of this thesis is to engineer quantum dot surfaces to make a quantum dot with minimal hydrodynamic size, negligible nonspecific interactions, chemical functionality and long stability for imaging cells and …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
<p>New therapeutic options are needed for glioblastoma, a deadly disease with a median survival of only 14 months with current treatment. The proteasome inhibitor bortezomib (BTZ) shows efficacy in cancers like myeloma, but its clinical utility in other cancer types has been more limited. Newer …
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
… with surgical resection and radioiodine therapy, survival drops precipitously in metastatic or radioiodine-resistant disease. 60% of papillary thyroid cancers (PTC) have an oncogenic V600E mutation in the kinase BRAF, which leads to a constitutively active and oncogenic kinase. This …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… determine how this subset affected combination therapy. Treatment with IL-12 and 4D5 significantly inhibited the growth of CT-26HER2, a murine cancer cell line that expresses human HER2. Combination therapy was associated with increased circulating levels of IFN-gamma, MIG and RANTES. IFN-gamma …
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Molecular imaging and gene therapy in experimental arthritis: a luminescent future for targeted therapy?
Contains fulltext : 150177.pdf (Publisher’s version ) (Open Access)
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Data Mining for Signal Detection of Targeted Therapy Related Drug Toxicity in Breast Cancer Patients
… patients with breast cancer treated with chemotherapy and 2,542 patients treated with trastuzumab in addition to chemotherapy. Inpatient and outpatient visits up to 1 year from start of therapy were used to identify adverse events (AEs). For each method two signaling thresholds were evaluated. …
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METFORMIN, CLIC1 AND TRANSCRANIAL STIMULATION: THE BASIS OF A NEW TARGETED THERAPY AGAINST GLIOBLASTOMA RELAPSE
… mass of the tumor, followed by chemoradiation therapy. However, this technique is neither effective nor specific, and tumor recurrence occurs frequently, often fatally. As a result, new techniques for preventing glioblastoma relapse and increasing patients' life expectancy should be developed. …
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Identifying TRAF1 Mutations as a Key Step to Develop a Targeted Therapy for Rheumatoid Arthritis
Rheumatoid Arthritis is an autoimmune disease characterized by chronic inflammation. Tumor necrosis factor receptor (TNFR)- associated factor 1 (TRAF1) has been implicated in disease development. TRAF1 is a signalling adapter downstream of TNFR and Toll-like receptors (TLR), where it plays opposing …
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Data Mining for Signal Detection of Targeted Therapy Related Drug Toxicity in Breast Cancer Patients
… patients with breast cancer treated with chemotherapy and 2,542 patients treated with trastuzumab in addition to chemotherapy. Inpatient and outpatient visits up to 1 year from start of therapy were used to identify adverse events (AEs). For each method two signaling thresholds were evaluated. …
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SMARCA4/BRG1-Inactivating Mutations as Potential Predictive Markers for Aurora Kinase A-Targeted Therapy in NSCLCs
SMARCA4 encodes a catalytic subunit of the SWI/SNF chromatin remodeling complex, BRG1. Frequent occurrence of SMARCA4/BRG1-inactivating mutations and their mutually exclusive nature from EGFR and ALK lesions create one of the largest subsets of Non-Small Cell Lung Cancers (NSCLCs). Since these …
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Novel Functions of Cetuximab In Egfr-Targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
… mechanisms underlying cetuximab-mediated EGFR-targeted therapy and to develop novel therapeutic strategies to improve the efficacy of cetuximab is urgently needed. In the present study, we elucidated the mechanism of cetuximab in radiosensitization, and discovered novel functions of cetuximab …
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Overcoming Resistance to CDK4/6-targeted Therapy Using JAK2/STAT3 Inhibitor in Triple-Negative Breast Cancer
… clinical evaluation of a novel combination therapy with two FDA-approved small molecule inhibitors for TNBC patients.</p>
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Investigating G-protein coupled receptors as novel biomarkers for diagnosis, prognosis, and targeted therapy in ovarian cancer
… as a diagnostic tool. In a second step targeted drug carriers could be selected depending on GPCR expression profiles leading to personalised treatment. In summary, this work highlights the theranostic potential of GPCRs, which could lead to a translational framework, combining …
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Characterizing The Effect of Dasatinib On Anti-Tumor Immune Response and Exploring The Potential of Combining Targeted Therapy and Immunotherapy In A C-Kit Mutant Mastocytoma Model
<p>Targeted therapy and immunotherapy eradicate malignant cells through different mechanisms, and the strengths and weaknesses of these two approaches are potentially complementary. Therefore, the combination of molecular targeted drugs with immune- based therapies is considered an attractive …
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Parallel Process: An Empirical Investigation
… study used a cross-sectional design in which 30 therapy relationships and the corresponding supervision relationships were studied. The therapist assessed the behavior manifested by the patient during a targeted therapy session. Following the subsequent supervision session, the supervisor …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… pathway and evaluate the potential of Akt-targeted therapy in a canine model of histiocytic sarcoma. We demonstrated Akt signaling to be active in 9 out of 10 canine HS tumor samples, regardless the presence of PTEN. Moreover, the Akt signaling pathway appears to be constitutively active in …
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Pharmacological management of leukemia in children
… care, treatment may include a mix of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant. The outlook or prognosis for an individual child is affected by the type of leukemia.
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Targeting head and neck squamous cell carcinoma through NQO1-mediated cytotoxicity
… by their resistance to traditional chemotherapy and radiotherapy modalities. Given that as diagnostic and therapeutic strategies in cancer treatment have seen great improvements over the last several decades, it would be only logical that the prognosis of HNSCC should improve. However, …
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