Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Targeted Nanoparticles"”.
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… through the application of perfluorocarbon nanoparticles carrying the direct thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginyl chloromethylketone, to impart focal anti-inflammatory and anticoagulant effects at sites of high thrombin activity. In this work, we demonstrate the ability of …
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Neuromuscular tissue-derived factors and inflammatory-cell-targeted nanoparticles for advancing brain health
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Nanoparticle systems that exploit host biology for diagnosis and treatment of disease
… This thesis aims to explore the potential of nanoparticles to interface with the host biology to perform systems-level applications that benefit disease sensing and treatment. First, we engineered nanoparticles to sense dysregulated protease activity associated with thrombosis and generate …
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Sulfur-Based Yolk-Shell Nanoparticles for Lithium Sulfur Batteries
… of gold-functionalized sulfur yolk-shell nanoparticles. Sulfur was chosen as a cathode material due to its high theoretical specific capacity (1675 mA h g−1). However, there are still many technical limitations for Li-S batteries, like the dissolution of the intermediate polysulfide and …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.</p> <p>Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for …
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Plasmonic Nanoshells: Synthesis, Functionalization, and Photonic Applications
… the photocatalyst in the composite material. The targeted nanoparticles reported herein were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and UV-visible (UV-vis) spectroscopy. Nevertheless, since GS-NSs not …
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Metal-organic frameworks as intracellular delivery vectors
… of MOF particles, a range of mitochondrially-targeted UiO-66 particles capable of bypassing endosomal entrapment was prepared and tested. The UiO-66 particles were loaded with dichloracetic acid (DCA), a small chemotherapeutic drug molecule that acts on mitochondria, and surface-functionalised …
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Design, Development, Characterization and Testing of CD22 Targeted Long Circulating Liposomal Drug Delivery Systems for B Cell Malignancies
… damage caused to cardiomyocytes by doxorubicin. Targeted delivery of AD 198 is crucial to moderate the non-specific interactions of the chemotherapeutic agent with healthy cells. The objective of this work was to design, develop and evaluate AD 198 loaded liposomal formulations for targeted …