Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Targeted Imaging"”.
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Engineered Nanomaterials for Targeted Imaging and Therapy
… facilitate the development of diagnostic imaging tools for earlier diagnosis and disease staging, and they can provide fundamental information on the pathological process. Nanoparticle probes have demonstrated to have numerous advantages over single molecule-based contrast agents, such as …
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Peptide targeted imaging of neutrophil invasion in cardiac tissue
The goal of this project is to engineer a benchtop model to test the efficacy of neutrophil blocking peptides, and provide a foundation for in vivo studies of peptide blocking. Current medical practices address the initial occlusion of heart flow by a surgical technique that re-opens the affected …
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Advancements in branched bottlebrush polymers for responsive, targeted imaging
… are promising platform materials for medical imaging and diagnostics. Specifically magnetic resonance imaging (MRI) and nearinfrared (NIR) fluorescent probes can be used in combination to visualize biodistribution and in vivo clearance rates. We reasoned that through the use of a nitroxide …
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Targeted Imaging Agents for Detecting Tumour Cell Death following Therapy
Cell death is an important target for imaging the early response of tumours to treatment. In this study a phosphatidylserine-binding protein (C2Am) has been derivatised with a fluorine-18 containing maleimide for imaging tumour cell death in a xenograft murine advanced colorectal cancer. A one-pot, …
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Development of Receptor-Targeted Imaging Agents: Integrated Gallium Complexes and Conjugated Cyclopentadienyl Tricarbonyl Rhenium and Technetium Complexes
… Photon Emission Computed Tomography (SPECT) imaging is 99mTc, the development of 99mTc-labeled phenyl-tropane analogs with high affinity for the dopamine transporter (DAT) would provide a useful tool for imaging disorders in this transporter system, such as clinical diagnosis of Parkinson's …
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Predicting peak load of the femoral neck using structural parameters
… and diseased bone, and provide indices for targeted imaging to better diagnosis osteoporosis.
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Targeting the receptor for advanced glycation end products with a quantitative multimodal imaging method for precision medicine
… suggesting its promise as a molecular target for imaging and therapeutics. In this work, we developed and employed a nanoparticle-based imaging strategy of RAGE, first in a model of hind-limb ischemia (a widely-studied pathological model for RAGE signaling), and subsequently in PCa. Finally, we …
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… and tissues. One such methodology is molecular imaging with positron emission tomography (PET), which allows for non-invasive visualization and quantification of spatial and temporal dynamics of expression-activity of various receptors and enzymes in different organs and tissues in norm and …
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Precisely size controlled drug-silica nanoconjugate for cancer therapy
… the size controlled dual-modal silica NCs for targeted imaging of metastatic lymph nodes was studied. By demonstrating the long term safety in preliminary toxicology studies and addressing several formulation/development issues (e.g. salt-stability, scalability and lyophilizability, etc.), we …
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Engineering Microbubbles with the Buried-Ligand Architecture for Targeted Ultrasound Molecular Imaging
… In addition, they are being developed for targeted diagnostic molecular imaging applications. Previous studies have shown that targeted microbubbles could induce complement activation and reduce their circulation persistence. In order to avoid the undesired immune response, a novel stealth …
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Development and Evaluation of Approaches for Quantitative Optical Molecular Imaging of Neoplasia
… three approaches for quantitative molecularly-targeted optical imaging of neoplasia. The first approach focuses on widefield imaging of biomarkers near the tissue surface for early detection applications; this approach is demonstrated in freshly resected oral tissue. Most oral cancers are not …
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Shortwave infrared imaging and its translation to clinically-relevant designs
… tissue is a central challenge in biomedical imaging, with both preclinical implications and clinical relevance. Using shortwave infrared (SWIR) light enables imaging with high resolution, high sensitivity, and sufficient penetration depth to noninvasively interrogate sub-surface tissue …
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Manganese porphyrin for Synthesis of Targeted Contrast Agents for Improving Specificity in Cardiac Magnetic Resonance Imaging
Specificity in imaging narrows our view from the physical anatomy of damaged tissues, to imaging the processes behind it. These are the benefits provided by nuclear medicine in oncology, whose contrast specificity is provided by chelated radionucleotides whose pharmacokinetics are controlled by a …
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New MRI Techniques for Nanoparticle Based Functional and Molecular Imaging
… use for several decades, magnetic resonance imaging: MRI) is undergoing a transition from a qualitative anatomical imaging tool to a quantitative technique for evaluating myriad diseases. Furthermore, MRI has made great strides as a potential tool for molecular imaging of cellular and tissue …