Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Targeted Delivery"”.
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Targeted delivery of biological agents
Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective …
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
… nutrient transporters i.e. SMVT and SVCT can be targeted to improve the delivery of poorly absorbed drugs such as anti-HIV PIs. Finally, the effect of common buffer component HEPES on the uptake and transport of P-gp substrates was carefully examined. It was found out that HEPES in the cell …
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Protein engineering for targeted delivery of radionuclides to tumors
… surgery only target known cancer sites. However, targeted therapeutics, such as antibodies, will bind to all cancer cells that express the targeted antigen, including small metastases that are invisible by current imaging technology. In the past decade, nine antibodies have been approved for the …
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USE OF DNA APTAMERS FOR TARGETED DELIVERY OF CHEMOTHERAPEUTIC AGENTS
… makes aptamers ideal candidates for drug delivery purposes.
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Self-assembled Polymeric Nanoparticles for Targeted Delivery of Anticancer Drugs
Targeted delivery of drugs to specific regions of the body, or even to specific regions of the cell, promises enhanced drug efficacy and reduced systemic toxicity. By covalently coupling targeting ligands, the smart drug delivery systems are capable of targeting specific cell types exclusively …
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Preparation and evaluation of tumour-targeted delivery systems for tocotrienol
… administration through the use of a tumour-targeted delivery system. Transferrin is an iron transporter whose receptors are often over-expressed in cancer cells due to high iron demand for tumour growth. Conjugation of transferrin to drug delivery systems appeared to be an attractive tool …
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Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
… exhibiting chemotherapeutic activity successful delivery remains challenging. Particulate-based system such as Nanostructured Lipid Carriers (NLCs) a new generation carrier allow encapsulation of drug and targeting of desired tissue. Resveratrol (RES) is a chemotherapeutic drug limited by its …
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Engineering translational multi-therapeutic targeted delivery vehicles for disease management
… To address this problem, development of delivery systems that are safe/less toxic, yet capable of housing and delivering higher, more efficacious doses with sophisticated levels of control over the delivery, timing, and/or sequence of release, in order to therapeutically re-wire these …
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Development of alternating amphiphilic copolymers for targeted delivery applications in cancer
… and treatment, a novel, highly adaptable, targeted nanoparticle system based on alternating amphiphilic copolymers has been developed having a variety of potential clinical applications. These polymers consist of an alternating copolymer backbone composed of hydrophilic polyethylene …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… therapeutic agent for CRPC and explores targeted drug delivery strategies to enhance its efficacy and specificity6. Eupenifeldin demonstrated potent cytotoxicity in multiple CRPC cell lines, with nanomolar IC₅₀ values and significantly lower toxicity toward non-malignant prostate …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… with healthy tissue and poor pharmacokinetics. Targeted drug delivery carriers can reduce systemic toxicity caused by off-target interactions, increase drug solubility and stability in physiological fluids, and improve efficacy through enhanced targeting and intracellular delivery to cancer …
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A platelet-mediated paradigm for the targeted delivery of microencapsulated, clot-augmenting biotherapeutics
Reported herein is a paradigm-shifting, targeted drug delivery system that leverages the patient’s own platelets to sense and actuate targeted delivery of a clot-augmenting therapeutic to a site of vascular injury. In this system, platelets target microencapsulated drugs through their natural …
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Engineering bacteriophage nanocarriers for targeted delivery of protein reagents to prostate cancer cells
… become some of the most effective reagents for targeted treatment and diagnosis of disease. The unique catalytic activity of some proteins and ability to bind disease-relevant receptors that can evade small molecule discovery, make these reagents well suited for use as therapeutic and bioimaging …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… (NHLBI) cited underappreciation of drug delivery systems as one of the attributed drawbacks.</p> <p>During ALI, the αvβ6/αvβ5 integrins of alveolar epithelium and endothelium, respectively play a critical role in mediating pulmonary edema in interleukin-1b (IL-1b) stimulated ALI models. A …
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Preparation and analysis of novel tumour-targeted delivery systems for prostate cancer therapy
… treatment of prostate cancer. Non-viral gene delivery is emerging as potential safer alternative to the use of viral vectors for the treatment of various gene related diseases including cancer. Although non-viral vectors may not be as effective as the viral ones, the continuous research on …
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… small size makes them potentially useful for targeted delivery of bioactive agents, and particles less than 200 nm in size will be readily uptaken by cells. NPs can be modified with functional groups to enhance their biological specificity. These characteristics make the NPs an ideal carrier …
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Assembly of Highly Asymmetric Genetically-Encoded Amphiphiles for Thermally Targeted Delivery of Therapeutics
… of CP drug-loaded nanoparticles that can be targeted to solid tumors by the external application of mild regional hyperthermia (39-43°C). </p><p>Highly repetitive ELP polymers were assembled by Plasmid Reconstruction Recursive Directional Ligation (PRe-RDL), in which two halves of a parent …
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Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis
… transcription. To enhance circulation time and targeted delivery efficiency, TFO was conjugated to M6P‑HPMA and showed efficient targeted delivery to HSCs. Two week short term in vivo i.v. administration also showed the therapeutic effects on liver fibrosis by M6P‑HPMA‑TFO.</p> <p>Transforming …
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Engineering layer-by-layer nanoparticles for the targeted delivery of therapeutics to ovarian cancer
… must be tailored to the particular drug-delivery challenges and opportunities posed by ovarian cancer. In this thesis, we designed layer-by-layer (LbL) nanoparticles (NPs) to target ovarian cancer using library-based approaches. Using this approach, we identified promising formulations …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
Summary Peptide-based drug delivery systems and therapeutics have gained an enormous attention during the last ten years. Progress in this field will lead to site specific delivery, improved receptor affinities, efficient cellular uptake and/or nuclear targeting. Thus, in this research project, …
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