Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Targeted Degradation"”.
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Targeted Degradation of Trinitrotoluene Using Iron (II)-Cyclodextrin-Peroxide Systems
… helped to improve the efficiency of Fenton degradation. This technique has also been successfully applied to remediate TNT contaminated soil systems (sand). Four systems were investigated: clean sand, sand and humic acid, sand and fulvic acid, sand and natural organic matter. This technique …
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Targeted Degradation of Intracellular Proteins using Ubiquitin Variant Induced Proximity
Eukaryotic cells rely on proteasomal degradation mechanisms to maintain protein homeostasis, quantity, and quality, essential for regulating various biological processes. A recent trend in drug development involves harnessing the ubiquitin (Ub)-mediated proteolysis pathway for the targeted …
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Novel Proteolysis Targeting Chimeras for the targeted degradation of the protein kinase CK2
… therapeutic strategy that can induce target degradation through the 26S proteasome, offering potential advantages in potency, selectivity, and prolonged biological activity. The aim of this project was to develop novel CK2-targeting PROTACs by conjugating a CAM4066-derived warhead to Cereblon …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… this role of Fak. Genetic deletion or targeted degradation with proteolysis targeting chimera (PROTAC) of Fak, but not inhibition of its kinase activity, restores interferon production and enhances the sensitivity of incipient and established metastases to Sting agonists and immune …
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Mechanisms underlying substrate engagement by TRIM7 and TRIM21 and strategies for re-directing their E3 ligase activity
… in substrate engagement in cells and subsequent degradation. The function of TRIM21 as a cytosolic antibody receptor has been firmly established – it can recognise antibody coated viruses that have managed to enter the cytoplasm and mediate their degradation. This feature of TRIM21 has also been …
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
… protein steady state levels via preventing AIP4-targeted degradation of LATS. Additionally, AIP4 binding to Amot130 leads to the ubiquitination and stabilization of Amot130. In turn, the Amot130-AIP4 complex signals the ubiquitination and degradation of YAP. This inhibition of YAP activity by …
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Complexation of Organic Guests and Coordination of Metal Ions by Cyclodextrins: Role of Cyclodextrins in Metal-Guest Interactions
… the ability to increase the efficiency of Fenton degradation of aromatic pollutant species. The increase in degradation efficiency observed in the CD Fenton reaction systems has been credited to the formation of a pollutant/CD/ferrous ion ternary complex which has the ability to produce hydroxyl …
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Computational methods for the structure-based design of protein-binding peptides
… inhibition of natural interactions, and targeted degradation of proteins. Despite advances in protein engineering, this remains a challenging task due to the large space of peptide structures and inaccuracies in atomic energy functions. In this thesis, I introduce new computational …
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Mechanism and Biological Scope of Target-Directed MicroRNA Degradation
… and actuated, although a number of miRNA-degradation processes and associated effectors had been proposed. One particular pathway discovered in 2010, named “target-directed miRNA degradation” (TDMD), was shown to cause miRNA degradation in the presence of unusually highly complementary …
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Analysis of the functions of phosphoprotein phosphatase 1 catalytic subunits during cell division
… To address this, I employed genome editing, targeted proteolysis, and quantitative phosphoproteomics to characterise the roles of the different PP1 catalytic subunits during cell division and to identify their potential substrates. I initially verified a method to synchronise large …
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Development and optimisation of food products low in FODMAPs: an investigation of dietary fibres in low FODMAP products and the reduction of FODMAPs via bio-technological processes
… α-galactosidase) were used to investigate the targeted degradation of fructans and GOS. Inulinase and invertase degrade both fructans and GOS, while α-galactosidase only degrades GOS. Inulinase was the most efficient in degrading both fructans and GOS since it led to the degradation of 90 % of …