Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Target-directed miRNA degradation"”.
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1
microRNAs (miRNAs) are short, ~22-nucleotide noncoding RNAs that base-pair to messenger RNAs (mRNAs) to direct their post-transcriptional repression through their associated Argonaute (AGO) proteins. Animal genomes encode hundreds of miRNAs that, together, regulate a majority of mRNAs and tune …
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Mechanism and Biological Scope of Target-Directed MicroRNA Degradation
MicroRNAs (miRNAs) are small, ~21 nucleotide RNAs that guide Argonaute (AGO) proteins to complementary target RNAs using base-pairing interactions. In canonical miRNA-mediated repression, AGO recruits repressive trans-acting factors to bound targets to promote their deadenylation, decapping, and …
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NEW FINDINGS INTO TARGET-DIRECTED MICRORNA DEGRADATION MECHANISM
MiRNAs are a class of small non-coding RNAs that function in post-transcriptional gene silencing by interacting with target RNAs. A novel mechanism in control of miRNA levels, called Target-Directed miRNA degradation (TDMD), has been described, which involves specific transcripts able to interact …