Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Target therapies"”.
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… should be considered for developing migration-target therapies against MB metastasis.
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… clinical nature of sepsis renders single-target therapies, such as antibiotics, fluid resuscitation and vasopressors, ineffective in many cases. This project aims to develop a series of multi-target drugs (MTDs) to address the various pathologies of sepsis, specifically targeting …
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Development of a Human Lung Cancer Cytochrome C-GFP Reporter Cell Line to Study Anti-cancer Drug Responses in Apoptosis Pathways
… the healthy human cells. Studies have shown that targeted therapies have been linked to activation of apoptosis signal pathways (cascade of caspases) in cancer cells including intrinsic and extrinsic pathways. One of the major pathways leading to caspase activation involves the release of …
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Differential expression of microRNAs in human External Cervical Root Resorption
… of its pathogenicity is lacking. Currently no target therapies are available. miRNA are crucial noncoding RNAs that influence cell signaling pathways including proliferation, apoptosis, and activation. This study aims to quantify the level of expression of miRNAs in ECR to target lesion …
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Identification and Characterization of Potential Novel Targets in Thyroid Carcinoma: Evidence of Non-Oncogene Addiction Unveiling Tumor Cell Vulnerabilities
… forms, characterized by a poor prognosis. Target therapies introduced in clinical testing are often unsuccessful; therefore, novel therapeutic strategies are needed. To identify critical nodal points for therapeutic intervention, our laboratory faced the “non-oncogene addiction” (NOA) …
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The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)
… unclear and limits the application of immune target therapies in the clinic. This thesis hypothesised that by understanding the biological responses to a minimum DNA damage in response to a low dose radiation in TNBC cells, new opportunities in reversing the chemoresistant status of this …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… experiments on animals in order to planning new target therapies.
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Design, development, and evaluation of novel polymer-drug conjugates and interpolymer complexes for the treatment of neurodegenerative disease.
… Current treatments are mainly symptomatic and target single pathways, offering limited impact on disease progression. Increasingly, multi-target therapies are being considered more effective for addressing the multifactorial nature of AD. However, such compounds face challenges such as poor …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… inhibitors (PARPi) emerge as potential targeting drugs for BRCA-deficient cancers including triple negative breast cancer (TNBC). However, it has been reported that a subgroup of patients even with BRCA mutation fails to respond to PARPi in multiple clinical trials. In this study, we …