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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 127 for “"Target of Rapamycin"”.

  1. Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae

    Pracheil, Tammy

    … and <em>in vivo</em> protein localization of fluorescence tagged proteins was employed to determine the function of an essential protein, Lst8, in TORC1 and TORC2 signaling and a previously uncharacterized complex, the Far3-7-8-9-10-11 complex (Far complex) in the budding yeast, …

    uno Repository record

  2. The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes

    Hukelmann, Jens LudgerUniversity of Dundee2014

    The serine-threonine kinase mammalian target of rapamycin (mTOR) is an important integrator of nutrient, cytokine and growth factor sensing in T cells and controls transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is …

    dundee Repository record

  3. Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin

    Bachmann, Rebecca AnneUniversity of Illinois at Urbana-Champaign2015

    … further investigated the regulation and function of mTOR cytoplasmic-nuclear shuttling. A systematic screen of mTOR revealed a rev-like NES sequence within mTOR at amino acids 1281--1289, which displayed robust nuclear export activity in a reporter system. Mutation of the conserved leucines within …

    uiuc Repository record

  4. The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease

    Sengupta, ShomitMassachusetts Institute of Technology2010

    … and cell growth. We have found that inhibition of mTORC 1 with rapamycin treatment suppressed whole-body postnatal growth similar to reduced caloric intake. We found that while feeding activated mTORC 1 in almost every tissue, there was variability in the upstream activating stimuli. The role of …

    mit Repository record

  5. Role of PRAS40 in mammalian target of rapamycin (mTOR) modulation in cancer and insulin resistance

    Malla, Ritu2018

    <p>Dysregulation of PI3K-AKT-mTOR pathway has been reported in various pathologies, such as cancer and insulin resistance. The proline-rich AKT substrate of 40-kDa (PRAS40), also known as AKT substrate 1 (AKT1S1), lies at the crossroads of these cascades and inhibits the activity of the mTOR …

    u-pacific Repository record

  6. Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms

    Workman, Jason J.2016

    <p>The gene expression profile of a eukaryotic cell is responsive to a variety of extracellular stimuli, including nutrient availability, which allows cells to toggle between anabolism and catabolism based on the favorability of their environment. Much of this information is relayed through …

    tenn-hsc Repository record

  7. Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes

    Rahman, Hazir2012

    The mammalian target of rapamycin (mTOR) is an intracellular protein kinase that plays a key role in the control of cell growth, differentiation, cell survival, and cell proliferation. In humans, mTOR deregulation is implicated in parasitic, fungal, bacterial and viral infections, immune disorders, …

    goettingen Repository record

  8. Effects of essential amino acids supply and body condition prepartum on antioxidant, inflammation and mechanistic target of rapamycin pathways in adipose tissue during the periparturient period

    Liang, YushengUniversity of Illinois at Urbana-Champaign2022

    … regulated in part via insulin and mechanistic target of rapamycin (mTOR) signaling. Nuclear factor, erythroid-derived 2-like 2 (NFE2L2, formerly Nrf2) is a key transcription factor controlling cellular oxidative stress (OS) in non-ruminants. Our research examined the effects of rumen-protected …

    uiuc Repository record

  9. THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION

    Serra, NicholasEast Carolina University2019

    … kinase signaling pathways to stimulate synthesis of proteins required for spermatogonial differentiation. The work presented here extends those findings, and is organized into chapters. In chapters 1-2, I present published studies describing key roles for 'mechanistic target of rapamycin kinase' …

    ecu Repository record

  10. Intramuscular Anabolic Signaling and Endocrine Response Following Different Resistance Exercise Protocols In Trained Men

    Gonzalez, Adam

    The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway appears to be the primary regulator of protein synthesis and growth. While resistance exercise paradigms are often divided into hypertrophy (HYP) and strength (STR) protocols, it is unknown whether these protocols …

    ucf

  11. Molecular signaling programs underlying neutrophil polarity and chemotaxis

    Cook, SaraUniversity of Illinois at Urbana-Champaign2014

    … elements for proper migration and recruitment of neutrophil cells, the underlying signaling networks remain poorly defined. We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine kinase, as a beta2-integrin-dependent regulator of rear contraction in migrating …

    uiuc Repository record

  12. Lysosomal nutrients and the mTORC1 pathway

    Wyant, Gregory A.(Gregory Andrew)Massachusetts Institute of Technology2019

    … is the major catabolic organelle, is the site of activation of the master growth regulator mTORC1 (mechanistic target of rapamycin (mTOR) complex 1), and is often deregulated in common diseases, such as cancer. Given the critical role of lysosomes in maintaining cellular homeostasis, a better …

    mit Repository record

  13. Signal transduction in human cells by metabolites derived from methionine and glucose

    Orozco, Jose M.(Jose Miguel Orozco Segrera)Massachusetts Institute of Technology2021

    … responses to their environment. The mechanistic Target of Rapamycin complex I (mTORC1) pathway integrates information from a wide range of nutrient inputs to appropriately control cell growth. Nutrients like amino acids and glucose are required for mTORC1 to localize to the lysosome, its site of …

    mit Repository record

  14. Differential BCAA Metabolism in Tissues of Tumor-Bearing Mice: A Path to Understanding Cancer Cachexia

    Zerrouk, Miriam2025

    … complex syndrome marked by muscle and fat loss, often resistant to nutritional support. While branched-chain amino acids (BCAAs) stimulate muscle protein synthesis, BCAA-targeted therapies have shown inconsistent results. In this study, a C26 colon cancer mouse model was used to examine how tumor …

    york Repository record

  15. Insulin and TSH signal transduction pathways in human preadipocytes.

    Bell, Andrea Dorothy Lee.University of Ottawa (Canada)2009

    Signaling through the rapamycin-sensitive mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal …

    ottawa-retro Repository record

  16. Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome.

    Layne, Andrew Steven2010

    <p>Exercise has been considered a cornerstone of diabetes prevention and treatment for decades, but the benefits of resistance training are less clear. Nineteen non-diabetic subjects (10 metabolic syndrome, 9 sedentary controls) underwent 8 weeks of supervised resistance training. After training, …

    etsu Repository record

  17. Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine

    Baranyi Nicholls, SebastianCarleton University2026

    … depressive disorder (MDD) is a leading cause of disability worldwide, with nearly one-third remaining treatment-resistant. Chronic stress is a major risk factor for MDD, whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid …

    carleton Repository record

  18. The localization of mTORC1 signaling

    Peterson, Timothy Richard, Ph.D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2010

    … appropriate activity levels and localizations of key signaling proteins. In eukaryotic cells, cell size is increasingly appreciated as being coordinated by the Target of Rapamycin (TOR) Pathway. TOR is a serine/threonine kinase that resides in two distinct protein complexes which in mammals are …

    mit Repository record

  19. Dysregulated DJ1-Mediated Translation in Alzheimer's Disease

    Uneri, AyseWake Forest University2018

    Alzheimer’s Disease (AD) is a form of dementia with aberrant synaptic transmission. It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis …

    wfu Repository record

  20. Modulation of plant growth by day length dependent regulation of the TOR signaling pathway

    Hamilton, FergaUniversity College Cork2022

    … environmental conditions to ensure the best use of their resources. This accurate regulation depends on the circadian clock, an internal time keeping mechanism that informs the plant of day length duration (photoperiod). The TOR (Target of Rapamycin) kinase pathway is a central hub where cellular …

    cork Repository record

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