Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Tapasin"”.
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Tapasin - The star of the show in HLA-I maturation
… machinery (APM). One of these proteins, tapasin, is of particular interest as it is dedicated to HLA-I and plays a key role in the selection and binding of peptides that induce stable HLA-I molecules. In this thesis I have studied HLA-I maturation, and tapasin in particular, both …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… immune responses. The first described-spliced tapasin (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, …
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Charakterisierung des molekularen Mechanismus der Stabilisierung des Peptidtransporters TAP durch das ER-Glykoprotein Tapasin
… eine Vielzahl an Hilfsproteinen einschließlich Tapasin (Tpn) und dem Transporter associated with Antigen Processing (TAP), der aus den nicht kovalent verknüpften TAP1- und TAP2-Untereinheiten besteht, reguliert. Das ER-residente Glykoprotein Tpn hat eine duale Chaperonfunktion, indem es die …
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Characterisation of TAPBPR in immune cells
… peptides on MHC-I is owed to the peptide editor, tapasin. More recently, a second peptide editor, named TAPBPR, was discovered. Together, they shape the MHC-I presented peptidome. However, unlike its homologue tapasin, TAPBPR catalyses peptide exchange independently of the PLC. It works closely …
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
… by two intracellular peptide editors, tapasin and TAPBPR. TAPBPR was shown to shape the peptide repertoire presented on MHC class I at the cell surface, either by directly catalysing peptide exchange on MHC class I molecules or by associating with the quality control enzyme …
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Characterising the immunopeptidome in hepatitis B
… Within this pathway, two homologous molecules tapasin and tapasin-related molecule TAPBPR optimize the peptide repertoire presented on HLA class I on the cell surface. TAPBPR is involved in both loading optimal peptides and preventing sub-optimal peptides from loading (filtering) and has been …
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Senescence and the Innate Immune System
… that NK cell activation is altered in cirrhosis. Tapasin and tapasin related protein (TAPBPR), both parts of the antigen presentation pathway are expressed in liver tissue and show a slight upregulation in liver disease. This suggests that aberrant expression via this pathway may be part of the …
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… MHCI by binding conserved surfaces required for tapasin association/function. CPXV203 is an 11-stranded β-sandwich consisting of two β-sheets stabilized by five disulfide bonds. CPXV203 topology is reminiscent of the poxvirus chemokine-binding family of proteins, though MHCI contacts largely …
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Characterization of antigen processing and presentation by peptide-linked MHC class I molecules
… Fibroblasten aus TAP-defizienten bzw. Tapasin-defizienten Mäusen sowie mit Hilfe von TAP-defizienten Maus-T-Lymphomzellen. Ich verwendete das aus dem Ovalbumin stammende Kb-bindende Peptid SIINFEKL in kovalenter Verknüpfung mit dem Aminoterminus von Kb- und Kd-Klasse-I-Molekülen, wobei …
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Utilising recombinant TAPBPR technology to investigate MHC class I peptide editing and therapeutic applications
… others undergo improved peptide editing when the tapasin E11-K20 loop is substituted, suggesting potential complementary functions of the two peptide editors. Finally, I analysed the effect of TAPBPR depletion on the presented peptidomes of a panel of HLA-A and -B molecules. Loss of TAPBPR led to …