Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Tankyrase"”.
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Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
… called Poly-ADP-ribose Polymerases (PARPs), are Tankyrases. There are two mammalian Tankyrases, Tankyrase 1 and 2, whose domain organization include ankyrin repeat clusters which mediate enzyme-substrate interactions and a SAM domain which regulates oligomerization of Tankyrase into large …
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Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
… were designed to bind to and inhibit the human tankyrase (TNKS), a key regulatory protein involved in Wnt signalling and overexpressed in cancer and other disorders. For this purpose, a tankyrase-binding peptide (TBP) was grafted between two adjacent repeats to create a solvent-exposed loop. A …
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Regulation of Protein Degradation by ADP-Ribosylation
… research aimed to reveal how the substrates of Tankyrase are degraded rapidly. Using Drosophila melanogaster, I described the role of Iduna E3 ubiquitin ligase in the regulation of Axin and Tankyrase proteolysis. I found that Iduna controls the proliferation of stem cells in the Drosophila …
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… inhibitors of PPIs involving two targets, Tankyrase (TNKS) the Anaphase Promoting Complex/Cyclosome (APC/C-Cdc20). TNKS belong to the poly-ADP-ribose polymerases (PARP) family of enzymes that PARylate their substrates, leading to ubiquitination and subsequent degradation. TNKS bind their …
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Glioma genetic profiling: The role of DNA repair and telomerase
… (human telomerase-associated protein 1), TNKS ( tankyrase), DCKI (dyskerin) and PARPI (poly (ADP-ribose) polymerase1 ) in human glioma compared to normal brain tissues and cell lines. Evidence suggests that hTERT was the only gene that was transcribed in all the glioma cell lines and tissues, …