Global ETD Search
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Showing 1 to 10 of 10 for “"Tangier"”.
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
… of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, characterized by extremely low plasma HDL cholesterol (HDL-C) levels and widespread storage of cholesterol in macrophages. We developed hepatocyte- and macrophage-specific ABCA1 knockout mice (HSKO and MSKO, respectively) and …
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Genetic polymorphism of the human apolipoproteins A and E
… of apo A-I and A-II in a patient homozygous for Tangier disease. It was also utilised to screen patients undergoing cardiac catheterisation, no variants of apo A-I and A-II were detected in this patient population. The presence of a minor apo A-IV variant in these patients requires confirmation …
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RARE ABCA1 VARIANTS FOUND ONLY IN AFRICAN AMERICANS AND HOW THEY AFFECT LIPID EFFLUX AND NASCENT HDL FORMATION
Discovery of Tangier disease and subsequent discovery of ATP binding cassette transporter A1 (ABCA1) as the gene responsible for the disease has changed the study of lipoproteins due to almost non-existent levels of HDL-C and increased atherosclerosis in these subjects. The idea that HDL-C and …
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The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes
… particles. In humans,ABCA1 deficiency results in Tangier disease, characterized by low levels of HDL cholesterol, cellular cholesterol accumulation and increased risk for atherosclerosis. More than 100 coding variants have been described in the ABCA1 gene. We attempted to understand how both …
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Contingent camps: An ethnographic study of contested encampment in the northern French and northern Moroccan borderlands
… frontier: between the headstones of an abandoned Tangier cemetery or the petrol pumps of an industrial zone in Calais. Through a deep ethnographic approach, this thesis tunes into the rhythms that govern encampment, the atmospheres inherent to these spaces and their effects on those who live them. …
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"The Perfect Scheme of it in his Head...:" Shaftesbury's Carolina Design in the Context of England's Atlantic Economy
… for lands in far flung places ranging from Tangier, Bombay, and the Gambia to Saint Lucia, Saint Eustatius, New Jersey, and the Carolinas. The Carolina charter of 1663 represented England's first serious attempt to make advances into the American southeast. Its success was critical in the …
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Kettle's Yard: anti-museum. H.S. Ede, modernism and the experience of art.
… he resigned from the Tate Gallery and moved to Tangier). This was a formative chapter in Ede’s life. I also seek to draw pertinent comparisons with other collection museums and ‘modernist’ institutions from that era. I begin with an introduction to Kettle’s Yard and to Ede himself. Chapter 2 …
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A mystic quest in the sheltering country : an investigation into Paul Bowles's literary image of Morocco
… a country of permanent residence. He settled in Tangier from 1947 until his death in November 1999. Paul Bowles’s work as a whole includes writings set in the different countries he travelled to but the bulk of his literary production is essentially Moroccan in themes, characters and settings. …
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Strategies for increasing investment in a city: A case for Buffalo City
… the world. The literature review also explores Tangier, a Moroccan City, which like Buffalo City has a river port which facilitated economic development providing local inhabitants with modern infrastructure and amenities, unlocking the economic potential of the city. Both qualitative and …
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Rediscovering the Heart of Public Administration: The Normative Theory of <i>In His Steps</i>
Public administration literature lacks richness and context regarding the moral history of the founding of the field in the early 1900s. As a result, current calls for "recapturing the soul" of public administration have failed to stimulate a theory-or even a working understanding-of how to …