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Showing 1 to 20 of 29 for “"Tandem mass spectrometry (MS)"”.
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Skysčių chromatografija–tandeminė masių spektrometrija antibiotikų nustatymui maisto produktuose /
… chromatography (UPLC) techniques coupled with tandem mass spectrometry (MS/MS) were developed for the determination of common antibiotics (chloramphenicol, sulfonamides and nitroimidazoles together with their metabolites) in food products. HPLC/UPLC and MS/MS conditions were optimized for the …
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Advance metabolite identification from tandem mass spectra using deep generative models
Tandem mass spectrometry (MS/MS) is a modern technique for measuring metabolites. MS/MS spectra represent molecules by the fragment patterns of compounds that contain structural features of the precursor molecules. The database-searching strategy is the most popular for metabolite identification …
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Mass Spectrometric Studies on Lignin Sequencing and Fast Pyrolysis, Functional-Group Selective Ion-Molecule Reactions and Reactivity of Bi- and Triradicals
… to the high sensitivity, selectivity and speed, mass spectrometry (MS) has proved to be an invaluable tool for mixture analysis and structural elucidation of mixture components. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice …
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Identification and enantioselective determination of protein amino acids in fertilizers by hydrophilic interaction and chiral chromatography coupled to tandem mass spectrometry /
… liquid chromatography coupled (HPLC) to tandem mass spectrometry (MS/MS) was involved for amino acids identification and enantioselective quantification studies. Direct amino acids identification assay in HPF samples was developed in hydrophilic interaction chromatography (HILIC) mode …
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Quantitative Approaches for Protein Differential Expression Analysis
In this work, tandem mass spectrometry (MS/MS)-based quantitative protocols were developed to facilitate differential protein expression analysis and biomarker discovery via a two-step sample interrogation strategy: (a) global protein profiling and differential expression analysis by spectral …
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MASS SPECTROMETRIC INVESTIGATIONS OF STRUCTURALLY DIAGNOSTIC ION-MOLECULE REACTIONS AND OF MOLECULAR STRUCTURES OF ASPHALTENES
Tandem mass spectrometry (MS/MS) has proven to be a powerful tool for the molecular-level characterization of components of complex mixtures due to its ability to study ionized molecules with high sensitivity, selectivity and specificity. By combining MS/MS with liquid chromatography (LC) to enable …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… esters and analyzed by electrospray ionization tandem mass spectrometry (MS/MS). Changes were observed in acetylcarntine (P=0.0125), glucose oxidation (P=0.0295), C16:1/C16:0 desaturation index (P= 0.0397), and C18:1/C18:0 desaturation index (P=0.0012). We did not find that individual changes in …
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Synthesis, Characterization, And Rna Reactivity Of Amino-Acid-Linked Cisplatin Analogues
… magnetic resonance (NMR) spectroscopy, and mass spectrometry (MS). Tandem mass spectrometry (MS/MS) combined with computational chemistry was also utilized to assess the effects of Pt(II) on the glycosidic-bond strength of the purine nucleoside, and to obtain an atomic-level understanding of …
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Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
… of the high specificity and sensitivity of tandem mass spectrometry (MS/MS) with the high separation ability of high performance liquid chromatography (HPLC) facilitates the sensitive and specific analysis in complex matrices like urine and blood. In this body of work, new methods were …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… individual tumor fragments for metabolomics. A tandem mass spectrometry (MS/MS)-based analytical platform was used to characterize 133 metabolites extracted from each tumor specimen. We then used a suite of statistical tools to identify metabolites differentiating H-met from L-met tumors. We …
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Development of a liquid-liquid, solid-phase extraction (SPE), LC-MS/MS analytical method for qualitative and quantitative drug residue analysis in white-tailed deer
… and managers struggle with animal health problems within the deer industry; as a result, veterinary drugs are used. The administration of antibiotics for treatment of infectious diseases may lead to residues in tissues. The quality and safety of food from animal origin is a growing concern for …
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Structural Analysis of Carbohydrates by Mass Spectrometry
… tools for detailed glycan structural analysis. Tandem mass spectrometry (MS/MS) is a powerful tool for structural analysis of carbohydrates with its high sensitivity and selectivity. MS2 (two-stage tandem mass spectrometry) is most often adopted due to the wide availability of commercial …
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Improving the Performance and Precision of Bioinformatics Algorithms
… and precision of bioinformatics algorithms used by biologists. Improvements in both the speed and cost of automated DNA sequencers have allowed scientists to sequence the DNA of an increasing number of organisms. One way biologists can take advantage of this genomic DNA data is to use it …
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Gene and Protein Expression in Human Gliomas
… origin or therapeutic sensitivity. The aims of this thesis has been to gain novel insights in the genetic and proteomic events underlying tumourigenesis and malignant progression in gliomas, and potentially define specific key events that could be the object of refined or novel therapeutic …
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Mechanistic studies of the radical transport pathway in aminotyrosine-substituted class Ia ribonucleotide reductase
… cannot overcome. To explain NH₂Y-RNR activity, mass spectrometry was used for relative quantitation of contaminating wt-RNR in the NH₂Y-RNR, lending credence to the fact that the NH₂Y-RNRs are actually inactive. These results provide clarity to the long-standing mystery behind the low activities …
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Determination of disulfide bond connecting patterns via tandem mass spectrometry (MSn) and biomolecular ion/radical reactions
… chromatography (HPLC) and then analyze them via tandem mass spectrometry (MS<sup>n</sup>). Although effective, the enzymatic digestion approach can be expensive, time consuming, nonspecific (some enzymes have a broad range of specificity), and sometimes initiate disulfide bond scrambling. The …
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Modern mass spectrometric techniques applied to occupational hygiene analysis.
… presence of a chemical substance can be great. Mass spectrometry is an analytical technique with a broad range of applications, described as the universal detector; the technique offers high sensitivity and high selectivity. Althomugh an established technique in many areas only limited …
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Diel patterns of insect herbivory and plant secondary metabolites in understory shrubs on Barro Colorado Island
… ionization and molecular fragmentation, and tandem mass spectrometry (MS/MS). Network analyses show that plant secondary metabolites varied greatly in their presence in leaves over the course of several hours, suggesting that ecologically significant differences exist in the overall chemical …
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Mass Spectrometric Studies on the Primary Products of Fast Pyrolysis of Carbohydrates and the Molecular Structures of Asphaltenes, and the Development of a Rastering Probe for Laser-Induced Acoustic Desorption into an Atmospheric Pressure Chemical Ionization Source
<p>Mass spectrometry (MS) has proven invaluable in the field of mixture analysis and structural elucidation. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice for structural elucidation of unknown analytes in mixtures. When coupled …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS). The pharmacological effects of bombesin-OS and bombesin-PE were tested. In addition, the antimicrobial activity and antibiofilm activity of AMPs were assessed and their haemolysis activity was also tested. Apart …
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