Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 163 for “"Tamoxifen"”.
-
Tamoxifen: Mechanisms of Resistance
… The selective estrogen receptor modulator tamoxifen was the first targeted therapy for the treatment of breast cancer. It was also the first drug approved by the FDA for the reduction of breast cancer risk. While tamoxifen has extended the lives of countless patients with breast cancer, …
-
Mechanism of tamoxifen resistance in breast cancer
<p>Acquired tamoxifen resistance develops in the majority of hormone responsive breast cancers and frequently involves overexpression of the PI3K/AKT axis. Here, breast cancer cells, with elevated endogenous AKT or overexpression of activated AKT exhibited tamoxifen-stimulated cell proliferation …
-
Tamoxifen metabolites can target both aromatase and estrogen receptors
… ER modulatory activity. Over the past 30 years, tamoxifen, a SERM, has become the most widely used drug for the adjuvant treatment of breast cancer. The metabolism of tamoxifen has a complex profile involving both active and inactive metabolites, among which endoxifen, 4-hydroxytamoxifen (4-HT) …
-
The mechanism of tamoxifen action on glioma cell lines
Tamoxifen, a member of the selective estrogen receptor modulator (SERM) family, is widely used in the treatment of estrogen-receptor (ER) positive breast cancer. It has been shown in previous studies that Tamoxifen exerts an antiproliferative effect in patients harbouring glioma. Glioma brain …
-
The Effects of Tamoxifen on Mammary Development in Prepubertal Heifers
… in prepubertal heifers given the anti-estrogen tamoxifen. Sixteen Holstein calves were randomly assigned to one of two treatment groups: tamoxifen-injected (TAM) or control (CON). Calves were subcutaneously injected daily from 28 to 120 days of age with 0.3 mg/kg tamoxifen or carrier. At 120 …
-
Aminoflavone Inhibits α6-integrin and Growth of Tamoxifen Resistant Breast Cancer
… develop resistance to standard of care agent tamoxifen, while ER negative (ER-) breast cancer patients are intrinsically resistant to tamoxifen. Resistance often promotes metastasis, recurrence and death. Tumor-initiating cells (TICs) represent key contributors to resistance and adhesion …
-
Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
… selective oestrogen receptor modulator (SERM) tamoxifen (broadly used in ER+ breast cancer) was effective on eradiating JAK2<sup>V617F+</sup> haematopoietic stem and progenitor cells (HSPCs) in preclinical mouse MPN models, which prompted a Phase-II clinical study (Effects of TAMoxifen on the …
-
The Relationship between Tamoxifen and Depressive Symptoms in Women with Breast Cancer
… with breast cancer and the presence of the drug tamoxifen, are more severely depressed than women with breast cancer and the absence of tamoxifen. Average Beck Depression Inventory (BDI) scores did not differ between the two sub-groups; however, two significant group differences were found. …
-
Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity
… MAP KINASE PHOSPHATASES 1 and 2 IN BREAST CANCER TAMOXIFEN SENSITIVITY</strong> </p> <p>by</p> <p> <strong>KELLY K. HAAGENSON</strong> </p> <p> <strong>May 2013</strong> </p> <p> <strong>Advisor:</strong> Dr. Malathy Shekhar</p> <p> <strong>Co-Advisor:</strong> Dr. Gen Sheng Wu</p> <p> …
-
Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
… (RB) protein pathway and associations to tamoxifen response. Furthermore, the expression of yes-associated protein (YAP1), reported to have both oncogenic and tumour suppressive functions, was investigated in breast cancer subgroups and related to tamoxifen response. Two of the key …
-
Localisation of sex steroid receptors and effect of Tamoxifen upon glioma cell lines in vitro
… and more recently an idea of prevention. Tamoxifen is a member of the selective estrogen receptor modulator (SERM) family, is widely used in the treatment of estrogen receptor (ER)-expressing breast cancer. It has been shown that a high dose of Tamoxifen has cytotoxic activity against …
-
Studies of Estrogen Receptor's Roles in Tamoxifen-Induced Apoptosis and the Regulation of Gene Expression
… of several classes of endogenous estrogen and tamoxifen-regulated genes. I concluded that phosphorylation of serine 118 is important for ER mediated gene transcription on some ERE-containing cellular genes while playing little role on other genes. Although estrogen and tamoxifen down-regulate …
-
Identification of therapeutic targets to revert tamoxifen resistance by quantitative proteomic analysis of signaling networks
Tamoxifen resistance is the biggest problem in endocrine treatment against hormone receptor positive breast cancer patients. HER2 is a membrane receptor tyrosine kinase that is known to correlate with poor disease outcome and unresponsiveness to endocrine treatment. Although much work has been done …
-
Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
… benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status alone is insufficient to predict treatment response. As a result, additional biomarkers are needed to predict resistance. The glucocorticoid …
-
IMMUNOMODULATORY ACTIVITY OF TAMOXIFEN AND RALOXIFENE IN MACROPHAGES: IMPLICATIONS FOR HOST-DIRECTED THERAPIES IN INFECTIOUS DISEASES
Tamoxifene (TAM) e raloxifene (RAL) sono modulatori selettivi del recettore degli estrogeni (SERMs), ampiamente prescritti per il trattamento di patologie dipendenti dal recettore degli estrogeni α (ERα), come il tumore al seno ERα-positivo e l’osteoporosi. Recentemente, questi farmaci hanno …
Page 1 of 9