Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Tal1"”.
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Resolving Cell Fate: Experimental, computational and mathematical methods in single cell transcriptomic analysis
… cells from other experiments were mapped. The Tal1-/- knockout mutant was characterised, reaffirming the known phenotype with complete failure of embryonic haematopoiesis. Analysing the Tal1-/- endothelial cluster shows definitively in the in-vivo organism no activation of an alternative …
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Studying early development using droplet single-cell RNA sequencing
… my investigation into the role of the genes Tal1 and T (also known as Brachyury) using chimaeric embryos. These genes are essential for proper development, and embryos die when they are entirely absent. Chimaeric embryos are composed of both knockout and wild-type cells: the wild-type cells …
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Mesoderm diversification during mouse embryonic development
… of disrupting the blood regulator $\textit{Tal1}$ using mouse embryonic chimaeras and reveal that endothelial cells are transcriptionally aberrant at early organogenesis and express genes characteristic of other mesodermal lineages. Although single-cell transcriptomics unveils the molecular …