Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Tak1"”.
-
The Role of Tak1 In Pancreatic Cancer Development
… to improve patient survival. We discovered that TAK1 is overexpressed in pancreatic cancer cell lines and patient tumor tissues. We demonstrated that the elevated activity of TAK1 is caused by its binding partner TAB1. Knocking down of TAK1 in pancreatic cancer cells with RNAi technique resulted …
-
BTB-Kelch Proteins and TAk1 Kinase N Immune Function
… at muscles and several photosensitive organs. TAK1 is a member of MAPKKK. Deletion of TAK1 prevented the maturation of CD4+ or CD8+ single positive thymocytes, leading to reduction of T cells in peripheral tissues. Thymocytes lacking TAK1 failed to activate NF-κB and JNK, and were prone to …
-
TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor
TGF-beta activated kinase-1 (TAK1) encoded by the MAP3K7 gene is a serine/threonine protein kinase that functions in the regulation of cell proliferation, apoptosis, differentiation and/or inflammation. Genetic studies have shown that hemizygous deletion of the MAP3K7 gene is frequent (32%) in …
-
The Role of TGF-B Activated Kinase (TAK1) in Retinal Development and Inflammation
Transforming growth factor β-activated kinase 1 (TAK1), a hub kinase at the convergence of multiple signaling pathways, is critical to the development of the central nervous system and has been found to play a role in cell death and apoptosis. TAK1 may have the potential to elucidate mechanisms of …
-
An investigation of the activation of protein kinase complexes in the MyD88 signalling network
The TAK1 and canonical IKK complexes are the two master protein kinases of the innate immune system that control the production of inflammatory mediators, but the mechanisms by which they are activated in this system are still unclear. In this thesis, I present the research I have carried out to …
-
Understanding The Role Of Transforming Growth Factor-β Activated Kinase-1 During Inflammation in Diabetic Retinopathy
The role of microglial TAK1 in inflammation during diabetic retinopathy is not well understood but is known to affect the health of neurovascular units through the activation of inflammatory factors and cytokines. Loss in barrier activity in the neurovascular unit leads to leukocyte infiltration …
-
Biochemical Mechanism of Protein Kinase Activation by the Ubiquitination System
… NF-κB is activated through activation of TAK1-IKK cascade by TRAF6 and Ubc13/Uev1A in a polyubiquitinationdependent manner. Mechanistically how TAK1 is activated by the TRAF6- Ubc13/Uev1A dependent polyubiquitination system is unknown. Whether TAK1 and IKK kinases can be activated by other …
-
Studies towards a fast and efficient total synthesis of LL-Z1640-2
… to selectively inhibit the kinase activity of TAK1. TAK1 (transforming growth factor β-activated protein kinase 1) is a major member of the mitogen activated protein kinase kinase kinase (MAPKKK) family. TAK1 is responsible for the activation and control of at least three signalling pathways …
-
Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… to the anti-fungal immune response<em>. </em>TAK1 and TRAF6 are critical nodes in NF-κB and MAPK activation downstream of immune surveillance and may be critical to the signaling cascade initiated by C-type lectin receptors in response to <em>C.</em> <em>albicans</em>. Macrophages derived from …
-
Phagosome proteomes in activated macrophages
… data suggest the specific recruitment of TAK1/MKK7/JNK signalling to the phagosomes in AAMΦ, which was confirmed by immunoblotting and fluorescence microscopy. I uncovered that K63 polyubiquitylation of phagosomal proteins is enhanced in AAMΦ, which is responsible for the translocation of …
-
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
… Hilfe eines Antikörper-Arrays sind die Kinasen TAK1 und Yes als herunterregulierte Gene nach LPXN-knockdown identifiziert worden. Abhängig von der Stärke der LPXN-Expression nimmt in PC-3-Zellen auch der Phosphorylierungsstatus der downstream von TAK1 stehenden Kinase JNK zu. Die …
-
Early and late events in NET formation
… that is under the control of the p38, MEK, and TAK1 signaling pathways, which govern the early phase of NET generation. Conversely, chromatin decondensation is a late event (occurring at 3-3.5 h as assessed by confocal microscopy) that is controlled by all signaling pathways known to affect NET …
-
New insights into a complex host-pathogen interaction: mechanisms of Helicobacter pylori activation of NF-κB
… transforming growth factor β-activated kinase 1 (TAK1), a MAP kinase involved in the NF-κB, AP-1 and JNK signaling pathways, and enhances the polyubiquitination and iii activation of the kinase. This lysine 63-linked ubiquitination is mediated by E3 ligase tumor necrosis factor receptor-associated …
-
Ubiquitin Mediated Regulation of NF-kappa B Signaling
… chains are required for the activation of TAK1, which leads to the activation of IKK. Activation of IKK leads to K48-linked ubiquitination, and the subsequent proteasomal degradation of IκBalpha . Two important areas of research focusing on ubiquitin regulation of NF-κB signaling are …
-
The Association Between The Il-1 Pathway
… MEK3, MEK6, JNK, P38, c-JUN, ECSIT, TRAF6, TAB1, TAK1, RKIP, NIK, IKKα, IKKβ, IκBα, and NF-κB.</p> <p>The individual SNP analysis proved to be interesting though inconclusive. There were some borderline significant results, such as associations of the SNPs rs16944, rs1143627, rs1071676, and …
-
Biochemical and Genetic Studies on CC2D1A, a new NF-κB Activator and a Regulator of Synaptic Functions
… domain ubiquitin ligase TRAF2, a protein kinase TAK1, and an essential regulator of IKK complex, NEMO. CYLD, a deubiquitination enzyme specific for Lysine-63 linked polyubiquitin chains, negatively regulates the activity of CC2D1A. These results suggest that CC2D1A activates NF-κB through the …
-
Mechanisms underlying enhanced bone marrow adipogenesis in diabetes
… the non-canonical TGFB-activated kinase 1 (TAK1)-mediated mechanism to inhibit adipogenesis. Transcriptome-wide gene expression profiling revealed a potential involvement of the Wnt pathway, confirming previous studies in our laboratory. Finally, I tested the effect of a known inhibitor of …
-
Identification and structural bioinformatics of druggable proteins in schistosoma species
… recent years. In this study, six putative AMPs (TAK1-TAK6) were identified to possess very strong anti-schistosomal capabilities using Hidden Markov Model. Added to this, glycosyltransferase and axonemal dynein intermediate chain schistosomal proteins were identified using in silico methods as …
-
Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… of components of both, the MAPK/Erk and the TAK1/MKK6 cascade, signal mediators of these pathways rank as candidates to mediate direct activation of Smad3. Smad3 is subsequently translocated to the nucleus and activates transcription in a Smad4-dependent manner. Negative regulation is …
-
Sensory Organ Morphogenesis in Caenorhabditis Elegans
… size control. The LIT-1 activator MOM-4/TAK1 is also important for compartment morphogenesis and both proteins line the glial sensory compartment. LIT-1 compartment localization is important for its function and requires neuronal signals. Furthermore, the conserved LIT-1 C-terminus is …
Page 1 of 2