Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Tail vein injection"”.
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… most likely to respond to specific drugs. In a tail vein injection mouse model of metastatic osteosarcoma, romidepsin increased survival and reduced respiratory distress in immunocompetent mice, but not in immunocompromised mice. This indicated that romidepsin may act on the immune system to …
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The Role Of Pkc Epsilon In Breast Cancer Cell Surface Polyfibronectin Assembly And Pulmonary Metastasis
… diminished ability to colonize the lungs in rat tail vein injection metastasis model. To further substantiate the role of PKC-epsilon in lung metastasis-mediating polyFn, mass spectrometry analysis was performed on the PKC-epsilon complex. Two proteins were identified and tested with …
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Thermoacoustic Imaging and Spectroscopy for Enhanced Cancer Diagnostics
… 20 dB in the center of a prostate tumor after a tail-vein injection of the contrast agent. Additionally, after direct subcutaneous injections of two different gold nanorods into a breast tumor, the concentration of each nanoparticle was discriminated in vivo with a signal-to-noise ratio of …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… cells were introduced into the circulation via tail vein injection, 20% of mice injected with Ckb KD cells developed lung metastases whereas 100% of mice injected with WT cells developed metastases. Likewise, when mice injected with WT PyMT cells were treated daily with a CKB chemical inhibitor, …
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A Study of the Therapeutic Potential of AF4 Mimetic Peptides
… of leukemic cells with SPK111 prior to tail vein injection effectively inhibited xenograft establishment. This suggests that SPK111 is effective on leukemia initiating cells and may be developed as an effective bone marrow purging agent. We also developed an ELISA for detection of serum …
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… in dogs and possibly even people. Chapter I entails a review of the past and current literature regarding immune interactions in canine osteosarcoma, as well as immunotherapeutic strategies investigated for the treatment of this canine cancer. Here we also briefly detail the clinical …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… approaches for this disease will require a detailed understanding of its immunogenomic profile. In this study, we combined targeted next generation sequencing and immunohistochemistry to analyze 122 gallbladder carcinoma tumor tissue samples from two cohorts in the United States (n=60) and …
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Effects of air pollution on vascular thrombosis
… administered via intratracheal instillation or tail vein injection 2, 6 or 24 hours prior to induction of thrombosis. The effects of DEP were compared with vehicle and suitable controls: carbon black (a clean carbon nanoparticle); quartz (a large non-carbon particle that causes …
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The effect of dietary genistein on breast cancer metastasis
The dietary isoflavone supplements are now perceived as safe and a natural alternative to hormone replacement therapy (HRT) and are recently being consumed by postmenopausal women. However, as weak estrogens, isoflavones may have the potential to alter breast cancer (BC) growth and metastasis which …
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Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery
… before the conjugation reaction. Following tail vein injection into rats, Gal–PEG–<sup>33</sup>P–ODN rapidly cleared from circulation and</p> <p>60.2% of the injected dose accumulated in the liver at 30 min post–injection, which was significantly higher than that deposited after injection of …
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Downregulation of miR-10a-5p as a Potential Therapeutic Target to Improve the Detrimental Effects of Post-stroke Social Isolation
… treated mice were given a 7 mg/kg dose via tail vein injection daily for three days following stroke. Three days after stroke was induced, mice were separated into their housing assignments. Baseline and post stroke behavior were evaluated to identify differences in post stroke outcomes. …