Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Tafazzin"”.
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The role of cardiolipin in the regulation of mitochondria-dependent apoptosis
… mostly due to the lack of cellular model. Tafazzin is a mitochondrial enzyme, which is mutated in Barth syndrome (BTHS) and is involved in the maturation process of CL. In BTHS, loss of tafazzin activity results in a decrease in mature CL, making it a good model to investigate the role of …
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Characterization And Identification Of Novel Regulators Of The Synthesis Of Phospholipids
… for defective growth and respiration in tafazzin-deficient cells. We demonstrate that these underlying defects of tafazzin deficiency are caused by the decreased CL/MLCL ratio, not by a deficiency in unsaturated CL. These findings have significant implications for the life-threatening …
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The temporal relationship between cardiolipin biosynthesis and remodeling enzymes and cardiolipin content during unloading atrophy in mouse soleus
… results in nascent CL which must be remodeled by tafazzin (Taz) to form the predominant CL species in mammals, tetralinoleoyl cardiolipin (TLCL). Previous research has shown that CL content and 18:2n6 composition decreased and Taz protein content increased in tenotomy-induced atrophied mouse …
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Identification of cellular functions of cardiolipin as physiological modifiers of barth syndrome
… which encodes a CL remodeling enzyme called tafazzin. BTHS patients exhibit a wide range of clinical presentations, indicating that physiological modifiers influence the BTHS phenotype. A targeted synthetic lethality screen was performed to identify physiological modifiers of CL deficiency. …