Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tacrine"”.
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The design and synthesis of novel tacrine analogues
… detosylated with sodium naphthalenide. Bridged tacrine analogues were investigated using norcamphor (210) and R(+)-camphor (212). All the resultant products were subjected to pharmacological assay and from inspection of the results further molecular design was possible. Synthetic routes were …
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Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase
… loss was 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Inhibition of AChE may present either therapeutic or toxic effects depending upon the dose administered. With the goal of discovering safe and effective pesticides to control the population of Anopheles gambiae, a malaria-transmitting …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… transporter(s) is limited. Here, I report that tacrine and bis(7)-tacrine are relative non-toxic anticholinesterases at solubility limits; however, the addition of verapamil enhances toxicity of both tacrine and bis(7)-tacrine to mosquitoes. Verapamil significantly increases the mortality of …
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Mild and Convenient Methods to Prepare N-Alkyl Tacrines
… first approved treatment for dementia symptoms. Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a reversible inhibitor of AChE. It was the first drug approved by the FDA for the treatment of cognitive symptoms of AD. Tacrine is now rarely prescribed as a drug for the treatment of AD due to its …
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Using Saccharomyces cerevisiae to characterise the in vivo effects of exposure to the prion-curing drug Tacrine and the fungal metabolite gliotoxin
… study, the effects of three prion-curing agents, Tacrine, 6-aminophenanthridine and Guanabenz on [PSI+] have been studied. The ability of all three drugs to cure [PSI+] has been demonstrated. From investigating the Tacrine mode of action, it appears that this drug may inhibit Hsp104p, a chaperone …
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Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease.
… since the cholinesterase inhibitors (ChEIs) (tacrine, donepezil, rivastigmine, galantamine) were introduced as treatments for AD. Multiple short-term randomised clinical trials of ChEI treatment show beneficial effects on cognition, global functioning and activities of daily living in AD. …
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Design and synthesis of novel non peptidomimtic beta-secretase inhibitors in the treatment of Alzheimer's disease
… lipoic acid and the AChE inhibitor (AChEI) tacrine, characterized by a tetrahydroacridinic moiety. Lipocrine is one of the first compounds able to inhibit the catalytic activity of AChE and AChE-induced amyloid-β aggregation and to protect against reactive oxygen species. Due to this …
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Molecular, Biochemical, and Toxicological Evaluation of Anticholinesterases for control of the Malaria Mosquito, Anopheles gambiae
Pyrethroids are the only class of insecticides approved by the World Health Organization (WHO) for use in insecticide treated nets (ITNs), the first line of malaria vector control. Widespread resistance development to pyrethroids undermines current control efforts, and hence an urgent need for …