Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Tabletability"”.
-
Tabletability Flip of Drugs upon Formulation
Tabletability is a key property that determines a powder’s ability to form tablets under applied stresses, typically represented by a plot of tablet tensile strength versus pressure. Tablet tensile strength reflects the contributions of interparticulate bonding area (BA) and bonding strength (BS) …
-
Ultrasound Assisted Processing of Solid State Pharmaceuticals. The application of ultrasonic energy in novel solid state pharmaceutical applications, including solvent free co-crystallisation (SFCC) and enhanced compressibility
… the main mechanism which caused the PAR form I tabletability to improve. It was found that the ultrasound–compacted tablets released the drug at a slower rate compared to pure PAR. This technique was shown to be useful for improving tabletability for low-compressible drugs without the need to …
-
Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… structure of paracetamol crystals to improve tabletability was the rationale. The modified particles, with the desired behaviour acquired, were characterised using FT−IR, PXRD, laser diffraction, SEM, DSC, TGA, Water absorption profile, flowability, stability, content uniformity, dissolution …
-
Role of Mechanical Stress, Excipients and Coprocessing On Tablet Mechanical Properties
… effect of compression speed on compressibility, tabletability, and compactibility profiles of various materials was explored. The advantage of utilizing a compactibility profile in reducing the effect of compression speed during tableting scale-up was evaluated. Strain rate sensitivity (SRS) of …
-
Engineering of composite pharmaceuticals with improved physicochemical and mechanical properties
… particles was also investigated. The poor tabletability and dissolution of indomethacin were overcome via milling and freeze-drying. The poor tabletability of metformin HCl was overcome by co-freeze-drying in the presence of polyvinylpyrollidone (PVP). The solid-state properties of the …
-
Engineering of Amorphous Active Pharmaceutical Ingredients by Sonoprecipitation and Spray Drying Pre-and Post-Processing Pharmaceutical Characterisation. Pre- and Post-Processing Physicochemical and Micromeritic Characterisation of Active Pharmaceutical Ingredients
… binary mixtures. In addition, NaCl content aided tabletability and dissolution of amorphous API composites with more viscous and high-Tg PVP polymers. Studies confirmed that application of factorial design facilitates robust design of production process of amorphous nanocomposites by …
-
Pharmaceutical formulation development utilizing hot melt extrusion and other techniques for development of immediate and controlled release dosage forms
… matrices were compressed into tablets and tabletability profiles generated. Simultaneously tablet hardness evaluation was performed using conventional characterization techniques as well as using a texture analyzer. HME tablets were more compressible and plastic nature in comparison to …
-
Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
Pharmaceuticals with suitable therapeutic properties often found to encounter challenges with dosage form development due to their poor physicochemical properties. Aim of thesis is to evaluate potential of crystal engineering directed cocrystallisation of active ingredients in modulating their …