Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"TXNIP"”.
-
Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes
… 100 and validated using qRT-PCR including Txnip, Gcg and Pcsk9. Txnip was up-regulated whereas Gcg and Pcsk9 were down-regulated in MIN6 B1(Non-GSIS) compared to MIN6 B1(GSIS). siRNA and shRNA silencing of Txnip in MIN6(H) (non-responsive) significantly increased the GSIS. Over-expression …
-
Integrating bioinformatics and physiology to describe genetic effects in complex polygenic diseases
… predominantly muscle. In paper I, we identified TXNIP as a gene whose expression is powerfully suppressed by insulin yet stimulated by glucose. In healthy individuals, its expression was inversely correlated to total body measures of glucose uptake. Forced expression of TXNIP in cultured …
-
Natural history and pathogenesis of Takotsubo cardiomyopathy
… activation of thioredoxin interacting protein (TXNIP). Evaluation of presence of nitrosative stress was performed in a rat model of TTC in parallel with human experiments looking at the local and systemic rise in the 3-nitrotyrosine (3-NT) as a footmark of ONOO⁻ formation. As a part of clinical …
-
The impact of glucotoxicity on pancreatic β-cell function
… displayed increased expression of ChREBP and TXNIP. Down-regulation of ChREBP and TXNIP in INS-1 832/13 cells cultured at high glucose suppressed high glucose-induced increase in VDAC1 expression. The cultured INS-1 832/13 cells also exhibited a reduced expression of VADC1 when resveratrol (a …
-
Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
… dependent on BRG1 in GICs. One of these genes is TXNIP, a major redox regulator that is also a negative regulator of glycolysis. We found that TXNIP expression in the GICs is regulated by both BRG1 and STAT3. Furthermore, using genetic and pharmacological means we demonstrate that BRG1 plays a …
-
Inflammatory Response Following Hemorrhagic Stroke: The Role of Cytokines
… to understand the changes that take place in the TXNIP-NLRP3 inflammasome following stroke and the therapeutic effects of verapamil on inflammatory, functional, and behavioral outcomes. This dissertation work adds to the body of literature on the relationship between inflammation, cytokine …
-
Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice
… and memory behaviors included Bcl2l11, Jun, Txnip, Chka, and Tgfb3. Interestingly, Tgfb3 has been previously linked to a significant QTL mediating strain-specific differences in hippocampal cell death after exposure to postnatal ethanol in BXD mice.</p> <p>When comparing ethanol-induced gene …
-
Cellular immune ontogeny and birth transcriptome in HIV-exposed uninfected infants
… ARRDC4 (2.3 fold, adjusted p-adj< 0.001) and TXNIP (1.4 fold, padj< 0.001). Gene-set enrichment analysis however, showed no significant enrichment or suppression of gene pathways in HEUs. Aim 2: HIV/ARV exposure did not have an interaction effect with age (all time points) in explaining the …