Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"TWIST1"”.
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TWIST1: a subtle modulator of neural differentiation and neural tube formation
… factors negatively regulated by ID1, reported TWIST1, along with only two other proteins. Twist1 expression is upregulated during in vitro neural differentiation. Furthermore, targeted deletion of Twist1 has dramatic consequences on anterior neural development. Twist1 knock-out mice fail to …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
… induces expression of the transcription factors Twist1 and Etv5. We demonstrate that Twist1 negatively regulates Th1 cell differentiation through several mechanisms including physical interaction with Runx3 and impairing STAT4 activation. Following induction by STAT3-activating cytokines …
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Role of ATRX in colorectal cancer metastasis
… of a selection of EMT-associated genes (namely TWIST1), and propensity to undergo EMT in response to TGFβ in vitro. I demonstrate that this loss of epithelial gene transcription is driven by loss of chromatin accessibility and transcription factor HNF4α activity at colonic epithelial gene loci. …
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The Role of TBX3 In Early Breast Cancer Progression
… of several EMT-related genes, including SLUG and TWIST1. Importantly, TBX3 is a direct regulator of SLUG, and SLUG expression is required for TBX3-induced migration and invasion. Assessing TBX3 expression in early stage breast cancers by immunohistochemistry (IHC) revealed high expression in …
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ING1 Impacts Ovarian Cancer by Altering EMT
… through binding to the promoter region of Twist1, the critical gene encoding transcription factor (TF) that induce EMT. Subsequently, ING1 promoted the expression of epithelial cell markers, including E-cadherin, while suppressing the expression of mesenchymal markers such as N-cadherin. …
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Investigating The Roles of Δnp63 As A Suppressor of Migration, Invasion, and Metastasis
… in turn regulate known EMT transcription factors Twist1 and Lef1. Alterations of ΔNp63 led to the development of various tumor types, among them mammary adenocarcinomas that were aggressive and highly metastatic. Focusing on this tumor type, we investigated ΔNp63’s role regulating mammary gland …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… in upregulation of the EMT master regulator, TWIST1, demonstrating a potential mechanism driving the transition to a mesenchymal phenotype. Fyn inhibition using siRNA or the clinical SFK inhibitor Dasatinib increased cell-cell adhesion in HaCaT-Ras cells over 6-fold (p<0.001) through a rapid …
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Development of Bioelectronic Technologies for the Investigation of Extracellular Vesicle Function and Anti-Cancer Drug Discovery
… immunoblot analysis showed that TEVs modulate TWIST1 protein amount but not DNA methylation level, and dual optical and electrical readouts of cell phenotype using OECTs were obtained. Further, heparin, a competitive inhibitor of cell surface receptors, was identified as an effective blocker of …