Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"TWEAK"”.
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TWEAK/Fn14 Pathway is Activated by Hypoxia and is a Novel Mediator of Retinal Neovascularization
… factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor inducible 14 (Fn14), have been implicated in angiogenesis but their role in retinal diseases is largely unknown. The purpose of my study was to evaluate the role of TWEAK/Fn14 pathway in NV. I used …
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Expressão imunoistoquímica de ácido retinóico, CRABP2, NFkB p100 e p105, TRAP1 e TWEAK em nefroblastomas
… CRABP2, NF?B p100/52, NF?B p105/50, TRAP1 e TWEAK tem sido descritos. Este estudo tem por objetivo a avaliação da expressão imunoistoquímica de ácido retinóico (AR), CRABP2, NF?B p100/52, NF?B p105/50, TRAP1 e TWEAK em amostras parafinadas de nefroblastomas correlacionando-a com fatores …
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
… necrosis factor-like weak inducer of apoptosis (TWEAK) have been implicated in the pathogenesis of LN and are thus potential biomarkers for disease activity monitoring. Methods: In this study urinary MCP-1 (uMCP-1) and TWEAK (uTWEAK), together with standard markers of disease activity, were …
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Correlation of urinary mcp-1 and tweak with renal histology and early response to therapy in newly biopsied patients with lupus nephritis in cape town, South Africa
… necrosis factor-like weak inducer of apoptosis (TWEAK) are secreted in the kidney and may be useful for predicting histological class, monitoring flares and assessing response to therapy. We assessed the utility of urinary MCP-1 (uMCP-1) and TWEAK (uTWEAK) in predicting renal histological …
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Investigating the use of omega three fish oils as protective agents against cytokine-induced skeletal muscle damage
… and TNFa/ TNF-related weak inducer of apoptosis (TWEAK) induced skeletalmuscle inflammation/wasting. Myogenesis was assessed by morphology andmyotube measurements or by qPCR of myogenic genes. Fibrosis was assessed byexpression of fibrotic proteins by immunocytochemistry or fibrotic genes by …
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Liver regeneration by hepatic progenitor cells
… of signalling pathways revealed and confirmed a TWEAK dependent activation of HPCs following macrophage transfer. Having demonstrated the potential for macrophage therapy via HPC activation, we aimed to study the ability of HPCs to regenerate the hepatic parenchyma. To do so we developed and …
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FCUDA: Efficient high-level automation CUDA-to-FPGA compilation
… by the programmers. The additional effort to tweak the code to enable efficient mapping of the tasks across the heterogeneous architectures cannot be ignored. In this thesis, a new code optimization flow is proposed. The flow will restructure and analyze the CUDA kernel code, optimizing the …
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A Gender -Specific Alcohol Use Disorders Screening Instrument: Validation of a Measure
… = 56.3%) at a hypothesized cut point of five. TWEAK had the highest sensitivity for females of 72.2% at its standard cut point; WOMAN Screen had the lowest sensitivity at the hypothesized cut point of five. Twenty percent of females experienced menstrual cycle irregularities during periods of …
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Exploring a Novel Mechanism of Reguation of the TNFR Family Member FN14
… own ligand TNF-like weak inducer of apoptosis (TWEAK). Given these results, it is thought that FN14 plays an important physiological role in the response to acute injury, and that FN14 activity is primarily regulated at the level of ligand and receptor expression. Various pathological states, …
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Automating the construction of a complier heuristics using machine learning
… performance, developers are forced to manually tweak their heuristics with trial-and-error experimentation. In this dissertation I present meta optimization, a methodology for automatically constructing high quality compiler heuristics using machine learning techniques. This thesis describes …
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A Stateful Web Augmentation Toolkit
… Profile module that identifies data records, a Tweak module that defines the look and behavior of an interactive widget, and a Storage module that persists the widget state across pages and browser sessions. Default implementations are provided for each module, and these implementations adhere …
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An interactive color pre-processing method to improve tumor segmentation in digital medical images
… outside the tumor are set to black. The user can tweak the color ranges in real time to achieve better results, in cases where the tumor pixels are non-homogenous in terms of intensity. The user then places a seed in the center of the tumor and begins segmentation. A pixel in the image is …
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The Gardener Architect: designing with the emergent natures of places
… inhabitants. These patterns set situations and tweak the dynamic processes over time. They choreograph the elements of architecture – the void, the climate, the resources and the living – whilst affording them agency. For a gardener architect, architecture is the improvisatory choreography of …
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Artist-Configurable Node-Based Approach to Generate Procedural Brush Stroke Textures for Digital Painting
… and artist-friendly way to define, share, and tweak brush textures used in digital painting.</p>
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Implementation of a Mathematical Approach to Rip Saw Arbor Design and Scheduling
… from a 1996 paper from Y. Fathi et al. We tweak the algorithm to accommodate the unique nuances of this particular plant and situation and we incorporate it into a wholistic arbor design and scheduling model. Finally, we discuss the challenges of implementing this complex model and ensuring …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… ligands. We identified three major hits - TRAIL, TWEAK and LIGHT that could synergise with IFN-γ to induce pro-inflammatory chemokines and cell death in colon cancer cell lines and primary human colonic organoids. In the last chapter (Chapter 4 of this thesis), we selected one of these hits- TRAIL …
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Designing and Evaluating Object-Level Interaction to Support Human-Model Communication in Data Analysis
… visual analytic systems that enable users to tweak model parameters directly or indirectly so that they may explore high-dimensional data. To study interactive data analysis, we present an interface, Andromeda, that enables non-experts of statistical models to explore domain-specific, …
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Care beyond justice: The conflicted ethics of drug treatment courts
… be better served by shared responsibility to tweak and tinker treatment to the always changing rhythms of life. Collaborative and communicative efforts to provide the best care are not helped by the threat of imminent punishment against the subjects of care. Many legal practitioners have …
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Algebraic and Logic Solving Methods for Cryptanalysis
… functions SHA-1 and SHA-2, we describe how to tweak the SAT solver using a programmatic interface such that the propagation of the solver and thus the attack itself is improved.
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