Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"TWAS"”.
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Integrative Approaches in Genomic Analysis: Advancing Epigenetic Prediction, Twas Methodology, and Cell-Type Deconvolution in Spatial Transcriptomics
… of transcriptome-wide association studies (TWAS). Similarly, methylome-wide association studies (MWAS) have been developed to explore the relationships between DNA methylation and disease, as DNA methylation plays a key role in regulating gene expression. In Chapter 2 of this dissertation, …
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ENHANCING BIOGAS PRODUCTION IN COLD-REGION WASTEWATER TREATMENT USING ULTRASONIC PRETREATMENT AND CO-DIGESTION WITH BREWER’S SPENT GRAIN
… of thickened waste-activated sludge (TWAS) and co-digestion using brewer's spent grain (BSG) as a co-substrate. The investigation of US pretreatment has recently become of interest worldwide for sludges since it can improve substrate solubilization by breaking down complex organic …
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Novel strategies for genomic and phenomic investigations of quantitative traits in maize (Zea mays L.)
… GWAS and transcriptome-wide association studies (TWAS) using transcriptome data from multiple tissues. Candidate genes from GWAS and TWAS revealed complex regulatory networks of physiological and biochemical pathways underlying root lodging. One of the most important factors that contributes to …
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Stochastic electron trajectories and wave interaction in relativistic gyro-traveling wave amplifiers
Gyro-traveling-wave amplifiers (gyro-TWAs) are types of gyrodevices, which take advantage of the cyclotron maser instability to produce coherent electromagnetic (EM) radiation from electrons gyrating in an external magnetic field and interacting with fast traveling waves. For high power …
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… and transcriptome-wide association studies (TWAS) has brought to light numerous genetic loci known or predicted to be involved in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in …
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Anaerobic co-digestion of municipal solid waste and sewage sludge.
… sludge (RAW), thickened waste activated sludge (TWAS) and simulated OFMSW. To facilitate organics solubilization, three pretreatments were evaluated: thermal, alkaline and thermochemical. Using a central composite experimental design, two factors were studied, the total solids content of the feed …
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Transcriptome-wide association analysis of survival in colorectal cancer patients
… Transcriptome-Wide-Association Study (TWAS) was conducted by applying the previously developed prediction algorithms on cohorts without gene expression (5674 individuals of the Study of Colorectal Cancer collected at the General Western Hospital (Edinburgh, Scotland) as well as 1948 …
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Improving Clinical Risk Models through Integration of Polygenic Risk Scores and Omics
… such as transcriptome-wide association studies (TWAS), but these methods tend to ignore functional mechanisms that play critical roles in gene-regulatory pathways, resulting in loss of predictive power. In this essay we present three integrative methodologies for improving disease risk prediction …
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Roles and Mechanisms of H3.1K27me1 Methyltransferases in Defense Against Virus in Arabidopsis
… Transcriptome-wide association studies (TWAS) reveled that the mutations of SAC3B, MBD9 and BRCA1 suppressed the enhanced expression of DNA repair-related genes and restored the viral resistance of atxr5 atxr6. In contrast, DNA repair factors such as ATM, ATR, RAD51, and RPA1A were …
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Germline variants associated with alternative splicing in colonic mucosa
… and in transcriptome wide association studies (TWAS) to identify new CRC predisposition loci.
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Common genetic variation and spliceosome variants in rare developmental disorders
Although thousands of rare disorders are caused by single, deleterious, protein- coding variants, evidence suggests that common variants also contribute to risk for rare, neurodevelopmental disorders (NDDs). These are likely affecting the penetrance of protein-coding variants as well as …