Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"TTP"”.
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Trends in clinical presentation and treatment outcomes in a South African TTP cohort
… secondary thrombotic thrombocytopenic purpura (TTP) in South Africa. Objectives: To assess the clinical presentations and outcomes of patients treated for HIV-associated and idiopathic TTP. Methods: We conducted a retrospective cohort study of patients consecutively diagnosed with TTP from 2010 …
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Design and Evaluate a Fair Exchange Protocol Based on Online Trusted Third Party (TTP)
… problems in the protocols that involve an online TTP.
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The role of MK2/TTP pathway in regulating early development and innate immunity in zebrafish
… MK2a is an RNA binding protein Tristetraprolin (TTP). bbp mutants lose the expression of YSL specific genes mxtx1 and mxtx2. Here, we show that these genes are regulated through their 3’untranslated region (UTR) by MK2a/TTP pathway required in the YSL during early zebrafish development to limit …
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Synthesis of fluorescent analogues of a-tocopherol as ligands for the human a-tocopherol transfer protein (a-TTP) /
… human a-tocopherol transfer protein (ha-TTP) utilizing fluorescent titration binding assays identified competent ligands for further use in protein studies. Compounds Id (C9-AO-a-Toc) and 2d (C9-NBD-a-Toc) both having nonyl alkyl chain extensions between the chromanol and fluorophore were …
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Investigation of the mechanism of transfer of a-tocopherol by the human a-tocopherol transfer protein (H-a-TTP) /
The human a-tocopherol transfer protein (h-a-TTP) is understood to be the entity responsible for the specific retention of a-tocopherol (a-toc) in human tissues over all other forms of vitamin E obtained from the diet. a-Tocopherol is the most biologically active form of vitamin E, and to date has …
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
… 3' untranslated region (3'UTR). Tristetraprolin (TTP) is an RNA-binding protein that plays a significant role in regulating the expression of ARE-containing mRNAs. Through its ability to bind AREs and target the bound mRNA for rapid degradation, TTP can limit the expression of a number of critical …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
… its ARE. In this thesis, I show that an AUBP, TTP, is dephosphorylated by LeTx and MAPK inhibitors, and knock-down of its expression stabilized IL-8 transcripts. LeTx activity also increased the colocalization of TTP to P-bodies, cytoplasmic sites concentrated with RNA decay enzymes. This …
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The Regulation of ARE-Mediated mRNA Decay During Colorectal Tumorigenesis
… The mRNA decay factor tristetraprolin (TTP), by virtue of its ability to bind AREs, promotes ARE-mediated mRNA decay by sequestering its target transcripts to P-bodies. Whereas TTP levels are low-to-undetectable in non-transformed cells, its expression is robustly induced by the …
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The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease with a reported incidence of 6 cases per million per year in the UK. It is characterised by episodes of microangiopathic haemolytic anaemia and thrombocytopenia, with the widespread presence of platelet-rich thrombi in …
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Decentralized Key Management for Beyond 5G Network Coding-Enabled Mobile Small Cells
… evaluation identifies that the fully distributed TTP (FD-TTP)-based key management solution has the greatest potential. This solution takes advantage of secret sharing techniques to establish a distributed TTP such that a threshold number of network users can collaboratively provide key management …
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Transfer pathways in higher education: exploring differences between pathway and nonpathway student success after university transfer in one state system
… to explore whether Tennessee Transfer Pathway (TTP) enrollment was associated with differences in student success outcomes after transfer to one of the University of Tennessee System (UTS) universities. The primary goals were to determine if differences existed in baccalaureate degree …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
<p>The tristetraprolin (TTP) protein family of RNA-binding proteins contains three widely expressed mammalian protein members: TTP (ZFP36), ZFP36L1, and ZFP36L2, all of which can regulate gene expression by binding to specific AU-rich sequences located in the 3'-untranslated regions (3’-UTR) of …
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The coordination and atom transfer chemistry of titanium porphyrin complexes
… The [eta][superscript]2-alkyne complexes, (TTP)Ti([eta][superscript]2-R-C≡C-R[superscript]') (where R = R[superscript]' = Me, Et, Ph; R = Me, R[superscript]' = Et), are prepared by treatment of (TTP)TiCl[subscript]2 with LiAlH[subscript]4 in the presence of the alkyne. The structure of …
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Development Of New Therapy to Combat Tuberculosis Induced Inflammation
… two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active TTP was infected with M. tuberculosis. TTP mutant mice showed reduced lung inflammation during early infection. Next studies examining the FhHDM-1 …
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Studies of ADAMTS13 expression and activity in the kidney
… leads to thrombotic thrombocytopenic purpura (TTP), which is either due to mutations (congenital TTP) or auto-antibodies (acquired TTP). The histopathological lesion is termed thrombotic microangiopathy and characterized by disseminated hyaline thrombi in the microvasculature of various organs …
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ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins
<p>Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins bind to AU-rich elements in the 3' untranslated regions of certain cellular mRNAs, leading to their deadenylation and destabilization. Studies in knockout mice have demonstrated roles for three of the family members, …
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Identification and reduction of pre-analytical errors in clinical chemistry through expert advice
… phase of the Total Testing Process (TTP). Preanalytical errors can occur at the time of patient assessment, test order entry, patient identification, sample collection, sample transport, or sample receipt in the laboratory. Previous work and clinical insights suggest that most errors …
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Supramolecular Porphyrin Assemblies: Photosynthetic Reaction Center Analogs and Porphyrin Networks
… states of the triad, protected triad, and Zr(TTP)(TTP-NH 2) in a given solvent are the same within experimental error. This result means that an electron is not transferring to the monomeric spacer porphyrin in high yield. Presumably, the DeltaG for this process is too unfavorable. Instead, …
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Accelerating time-to-market in the global electronics industry
… fast time-to-market (TTM) and time-to-profit (TTP) is key to customer satisfaction and firm competitiveness. Optimizing the product development and new product introduction (NPI) process is particularly critical for products in dynamic market segments such as consumer electronics and …
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