Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TSP1"”.
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Grk3 Connects Angiogenesis and Neuroendocrine Differentiation In Prostate Cancer By Activating Hdac2 That Epigenetically Represses Tsp1 and Rest
… (the master repressor of neuronal genes) and TSP1 (a potent anti-angiogenic factor). Therefore, GRK3 is the key molecular link between angiogenesis and neuroendocrine differentiation. Interestingly, GRK3 phosphorylates HDAC2, which binds to the promoters of REST and TSP1 to repress their …
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Contribution of the Microenvironment in Bone Resident Cancer: the Role of Thrombospondin-1 in Bone and Risk Loci Contributing to Multiple Myeloma
… the role of bone-resident Thrombospondin-1 (TSP1), a glycoprotein with well-documented roles in promoting cancer growth. Chapter 3 is focused on the identification of genes conferring inherited susceptibility to multiple myeloma that participate both in malignant cells and in host supportive …
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The Role of Dermal Architecture in Wound Healing and Tumour Differentiation
… collagen alpha 1 (COL5A1) and thrombospondin 1 (TSP1) were upregulated in RDEBF and UVSCCF fibroblasts, and further upregulated in RDEBSCCF fibroblasts (Ng, Pourreyron et al. 2012).<br/><br/>Following these observations, the work done in this thesis attempts to further elucidate the contributions …
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Strain improvement and characterization of antibiotic producing microorganisms from soil
… of 99.68% with Staphylococcus sciuri. Isolate TSP1 sequence had a sequence identity of 100% with Pseudomonas formosensis strain CC-CY503. The production of antimicrobial substances started on the 4th day and went on increasing till it reached a maximum peak on the 7th day. The optimum growth …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… suppresses the expression of thrombospondin 1 (TSP1) in order to induce angiogenesis, thus acting as a mediator for the β-adrenergic signaling pathway.</p> <p>Here, we have introduced two new pathways acting downstream of the ADRB2/CREB axis. We show that the CREB/GRK3 axis leads to …