Global ETD Search
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Showing 1 to 7 of 7 for “"TSP-1"”.
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A plazma XIII-as faktor hatása a vaszkuláris simaizomsejtek funkcióira
… fehérjéké, mint a thrombospondin-1 (TSP-1) csökken. Munkánk során vizsgálni kívántuk a TSP-1 fehérje aktivált FXIII kezelés hatására bekövetkező változását elkülönülten a simaizomsejtek lizátumában és az extracelluláris mátrixban, valamint a FXIII-A hatását a vaszkuláris …
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
… of the angiogenesis inhibitor Thrombospondin-1 (Tsp-1) requires stimulation of Myc in combination with hyper-physiologic levels of oncogenic Ras. This work demonstrates that in human mammary epithelial cells, repression of Tsp-1 requires the activation of Myc by a Ras-induced pathway that …
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The effect of EGFL7 on the TGF-β/BMP family
… æðamyndunar. Einnig hefur verið sýnt fram á að TSP-1 hindri æðamyndun í æðaþelsfrumum og að æðaþelspróteinið EGFL7 geti leitt til aukins frumuskriðs í fylgjumyndun. Takmörkuð þekking er á undirliggjandi ferlum íferðar næriþekjufrumna en tilgáta rannsóknarhópsins að EGFL7, í gegnum EMI hneppið, …
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Andstæð hlutverk TGF-ß fjölskyldunnar í fylgjumyndun og meðgöngueitrun
… og þannig auka líkurnar á meinvörpum. TSP-1 er náttúrulegur æðahindri sem tjáður er í fylgjunni en hlutverk þess er óþekkt í fylgjumyndun. TSP-1 hefur áhrif á ýmsa frumuferla svo sem frumuskriðsviðloðun. Markmið verkefnisins er tvískipt. Í fyrsta lagi að athuga hvort TGF-ß fjölskyldan …
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The interaction of angiocidin and tissue transglutaminase
… using a peptide fragment of thrombospondin-1 (TSP-1), a matrix protein that has been implicated in mechanisms of tumor progression. The recombinant protein was expressed and shown to be a potential inhibitor of angiogenesis but the mechanism of action was not characterized. Affinity …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… growth factor-A (VEGF-A) and thrombospondin-1 (TSP-1). The objective of this dissertation was to examine how alterations to the microenvironment impacted the appropriate microvascular remodeling responses to alterations in flow. The skeletal muscle microenvironment was altered through …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… integrity. miR-133a-5p suppressed COL3A1 and TSP-1 expression, limiting vascular permeability and leukocyte recruitment. Furthermore, miR-133a-3p promoted ADAMTS-1 expression under TNF-α stimulation, supporting ECM remodelling, while miR-133a-3p also induced ICAM-1 expression in response to …