Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"TSLP"”.
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TSLP-induced Mechanisms and Potential Therapies for CRLF2 B-cell Acute Lymphoblastic Leukemia
… for the cytokine Thymic Stromal LymphoPoietin (TSLP) on the surface of B-ALL cells. TSLP has been shown to induce proliferation of human and mouse B-cell precursors via activation of the JAK-STAT5 and more recently the PI3K/AKT/mTOR pathways. However, the mechanisms by which TSLP-CRLF2 …
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Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… the IL-7R ligands, thymic stromal lymphopoietin (TSLP) and IL- 7, in the early stages of normal postnatal and adult human B cell development. Using novel in vitro and in vivo model systems, we show that TSLP and IL-7 are able to expand B cell precursors individually and in combination from CB …
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The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
… cytokine thymic stromal lymphopoietin (TSLP) plays a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that characterize asthma. Current models suggest that TSLP is produced by epithelial cells in …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… cells to produce Thymic Stromal Lymphopoietin (TSLP), an IL7-like cytokine, which potently activated human myeloid dendritic cells (mDC) to cause the homeostatic proliferation of autologous CD4+ T cells that serve as targets for HIV infection. Rhesus macaques inoculated with simian …
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Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… of lymphokines and other immune mediators (e.g., TSLP) by IECs, which then modulate the intestinal immune compartment. We hypothesized TSLP could be contributing to the decrease in CD103+ DCs as it is an important cytokine involved in TH2-type immunity and plays a key role in the maintenance of …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
… the cytokine thymic stromal lymphopoietin (TSLP) in response to topical administration of the vitamin D3 analog MC903. Widespread increases in Tregs were observed in mice treated topically but not systemically with MC903. TSLP receptor (TSLP-R) but not hematopoietic vitamin D receptor …
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The Use of Surface Cytokines as Biomarkers in B Cell Mediated Autoimmune Diseases
… patients. As discussed above, APRIL, BAFF and TSLP have been implicated in the pathogenesis of RA and SLE. Current therapeutics used to treat RA and SLE provide sub-optimal response in a third of patients treated. Therefore, identifying subsets of patients based on their surface and soluble …
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RBPjk-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals
… animals. Although the levels of epidermal TSLP expression are similar in all Notch mutants, RBPjcKO hair follicles are less distorted and produce less TSLP leading to lower serum TSLP levels. The reduced TSLP in serum results in less aggressive B cell expansion allowing RBPjcKO animals to …
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Reprogramming the immune environment in breast cancer via dendritic cells.
… cells produce thymic stromal lymphopoietin (TSLP). Breast tumor supernatants, in a manner dependent on TSLP, induce expression of OX40L on dendritic cells (DCs). OX40L⁺ DCs are found in primary breast tumor infiltrates. OX40L⁺ DCs drive development of inflammatory Th2 cells producing …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… alarm by secreting thymic stromal lymphopoietin: TSLP), an epithelial-derived cytokine implicated in pathogenesis of asthma and atopic dermatitis. TSLP was highly expressed by Notch-deficient epidermis. Importantly, we were able to show that TSLP was both required and sufficient to cause a lethal …
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Immune activation at the lung epithelial barrier
… epithelial-derived thymic-stromal lymphopoietin (TSLP) did not play a role in a mild model of HDM-induced asthma. However, the use of higher doses of HDM (inducing more severe asthma features) revealed a more important role for TSLP. In conclusion, this thesis shows that lung DCs are important for …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… and reduced systemic type 2 cytokines, TSLP, IL-5, and IL-13 producing CD8 T cells. Furthermore, type 2 alarmin, TSLP was reduced at disease site. These results suggest a dichotomy of IL4i1 in regulation of type 2 immune responses depending on disease site. This data further suggests …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… including CXCL1, CCL11, IL-6, IL-9, and TSLP, in shaping macrophage function within the LN microenvironment. To determine whether macrophages contribute directly to fibrosis, we examined the effects of TGF-β and LN patient serum on macrophage reprogramming. Renal biopsy transcriptomic …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… in overexpression of the pro-Th2 cytokine Tslp and the proinflammatory cytokine Tnfα. Increased transcript levels of Il-1β, the Th17 type cytokine Il-17α and Il-23 were also observed in Spink5-/-Klk5-/- epidermis and strong infiltration by mast cells. In addition, aberrantly high …