Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TSHR"”.
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Development of Cochlear Nonlinearities in Normal and Tshr Mutant Mice
… and a strain commonly referred to as the hyt, or Tshr mouse. The Tshr mouse expresses a naturally occurring point mutation in the gene that encodes the thyrotropin receptor resulting in the loss of its ability to bind thyroid stimulating hormone, a condition that leads to thyroid gland hypoplasia …
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Cryo-EM studies of class A GPCRs: the thyroid-stimulating hormone receptor and the β1-adrenoceptor
… the thyroid-stimulating hormone receptor (TSHR) and the β1-adrenoceptor (β1AR) were studied. The TSHR is a class A GPCR that belongs to the family of glycoprotein hormone receptors. It carries a large extracellular domain (ECD) that binds to the endogenous ligand, the thyroid stimulating …
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The evolution of the autoantibody response in Graves’ disease
… (TSAbs) activating the thyrotropin receptor (TSHR). Both genetic and environmental factors contribute to pathogenesis and one such factor is the infectious agent, Yersinia enterocolitica. Two high affinity TSAbs, (KSAbl, lgG2t>/K; KSAb2, IgGaa/K), developed from an experimental murine model of …
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Aberrant Communication and Protein Kinase C in Experimental Autoimmune Thyroiditis
… to abnormal receptor function, we measured TSHr expression (density), and modulated pKA activity and intercellular levels of cAMP. We found diseased thyrocytes had an increased density of TSHr that was not directly linked to pKC and was not responsible for the increase in pKC activity. The …
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Biomechanics of Cardiac Remodelling in Heart Failure
… with angiotensin-converting enzyme inhibitors (TSHRs), as well as Wistar-Kyoto (WKY) controls. These animals were studied at three time-points, 3 months (mo), 14 mo and 21 mo. Each animal underwent cardiac magnetic resonance imaging (MRI) and in vivo pressure measurements, which allowed for …