Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TSG-6"”.
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The Role of Tumor Necrosis Factor-Stimulated Gene 6 Protein (TSG-6) in Osteoarthritis
… Tumor Necrosis Factor-Stimulated Gene 6 (TSG-6) was identified to be significantly associated with OA progression and validated in both medial and lateral compartment dominant OA samples. </p><p>Next, we explored mechanisms underlying the association of TSG-6 with OA progression. We …
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Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses
… mediated by CAF-secreted TNF stimulated Gene 6 (TSG-6). Our findings in murine and human samples suggest that TSG-6 interacts with CD44+ myeloid cells in the TME, contributing to their suppressive phenotypes. High TSG-6 levels correlated with poor prognosis in patients treated with ICT, and …
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Role of Covalent Modification of Hyaluronan with Inter-Alpha Inhibitor Heavy Chains During Acute Lung Injury
… secreted enzyme TNFα-stimulated gene-6 (TSG-6). Mice deficient for HC-HA formation, due to the lack of either TSG-6 or IαI, display reduced survival during systemic lipopolysaccharide (LPS)-induced endotoxic shock and its associated acute lung injury. We therefore hypothesized that HC-HA …
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Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture
… IL-6 and PGE2, and gene expression of SDF-1 and TSG-6. IFN𝛾 and TNFα were not produced by eBMSC spheroids and IL-10 production varied between individuals. Spheroids maintain higher viability and lower senescence than monolayer eBMSCs after injection through a needle and form in high-throughput …
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The Role of Hyaluronan in the Ocular Surface
… higher expression of HA binding proteins TSG-6 and IaI heavy chains in the limbal region. (3) Has1-/-;Has3-/- knockout mice did not show signs of ARMGD at 1yr. of age and minor gland atrophy and dropout at 2yrs. of age in comparison to the wild type mice. (4) The non-human primate …